Agent Name

N-Methyldiethanolamine

CAS Number

105-59-9

Formula

C5-H13-N-O2

Major Category

Nitrogen Compounds

Synonyms

2,2'-(Methylimino)diethanol; 2-(N-2-Hydroxyethyl-N-methylamino)ethanol; Bis(2-hydroxyethyl) methyl amine; Bis(2-hydroxyethyl)methylamine; Ethanol, 2,2'-(methylimino)bis-; MDEA; Methylbis(2-hydroxyethyl)amine; N,N-Bis(2-hydroxyethyl)methylamine; N,N-Di(2-hydroxyethyl)-N-methylamine; N-Methyl-2,2'-iminodiethanol; N-Methylaminodiglycol; N-Methyldiethanolimine; N-Methyliminodiethanol; 2,2'-Methyliminodiethanol; Ethanol, 2,2'-(methylimino)bis-; Ethanol, 2,2'-(methylimino)di-; Methyl diethanolamine; [ChemIDplus] 2,2`-(Methylimino)bis-ethanol; Diethanolmethylamine; [ICSC] EVE; MDEA (diol); Methyldiethanolamine; Methyliminodiethanol; N-(2-hydroxyethyl)-N-methylethanolamine; N-Methylbis(2-hydroxyethyl)amine; [CAMEO] Amietol M12; Methyldiethanolamin; [IUCLID]

Category

Ethanolamines

Description

Colorless liquid; [ICSC] Clear light yellow liquid; [Sigma-Aldrich MSDS]

Sources/Uses

Used as an intermediate, to absorb acidic gases, as catalyst for polyurethane foams, and pH control agent; [HSDB] Used in chemical syntheses (i.e. pharmaceuticals and cationic surfactants), as a cleaning-washing agent, pH regulator (coating manufacture), and solvent (removal of acid gases in oil refineries); [IUCLID] Used to make fine and large scale chemicals, as a catalyst in polymerization reactions, laboratory reagent, additive in coatings and concrete-cement, in gas treatment, and lubricants and metalworking fluids; [ExPub: ECHA REACH Registrations] Permitted for use as an inert ingredient in non-food pesticide products; [EPA]

Comments

Causes ataxia and diarrhea in oral lethal-dose studies of rats; Causes changes in bladder and adrenal weights and methemoglobinemia-carboxyhemoglobin in 9-day intermittent dermal studies of rats; [RTECS] Not a skin sensitizer in guinea pig maximization study; Moderate to severe skin irritation but no systemic toxicity observed in 90-day dermal study of rats at doses up to 750 mg/kg/day; [IUCLID] A skin and eye irritant; [ICSC] An eye, nose, throat, and strong skin irritant; May cause second degree skin burns after a few minutes contact; [CHRIS] A mild skin and strong eye irritant; Harmful by ingestion; [Sigma-Aldrich MSDS]

Exposure Assessment
Vapor Pressure

0.0002 mm Hg

Lethal Concentration

LC (rat) > 6.5 mg/m3/6hr

Flammability (NFPA)

1: Must be preheated

Adverse Effects
Methemoglobinemia

Methemoglobinemia, Secondary

Dermatotoxin

Skin Burns

Links to Other NLM Databases
Health Studies

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Toxicity Information

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Chemical Information

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Processes

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