Agent Name

1-Methylpiperazine

CAS Number

109-01-3

Formula

C5-H12-N2

Major Category

Nitrogen Compounds

Synonyms

4-Methylpiperazine; N-Methylpiperazine; Piperazine, 1-methyl-; [ChemIDplus] UN2734

Category

Piperazines

Description

Clear light yellow hygroscopic liquid; [Sigma-Aldrich MSDS]

Sources/Uses

Used to make large scale and fine chemicals; [ToxPlanet: ECHA REACH Registrations]

Comments

Causes skin corrosion in acute dermal studies of rabbits; Causes convulsions in acute inhalation studies of mice; Causes multiple liver effects, changes in renal tubules, changes in recording from peripheral motor nerve, and general anesthesia in acute oral studies of mice; [RTECS] Causes burns; May cause skin sensitization; Harmful by inhalation; [ToxPlanet: ECHA REACH Registrations] Causes burns; Inhalation may cause corrosive injuries to upper respiratory tract and lungs; Harmful by skin absorption; Toxic by inhalation; [Sigma-Aldrich MSDS] See "Piperazine and salts."

Exposure Assessment
Vapor Pressure

3 mm Hg

Lethal Concentration

LC50 (mouse) = 2,740 mg/m3/2hr

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Amines, liquid, corrosive, flammable, n.o.s."

Adverse Effects
Skin Sensitizer

Yes

Toxic Pneumonitis

Yes

Hepatotoxin

Hepatotoxin, Secondary

Dermatotoxin

Skin Burns

Links to Other NLM Databases
Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Biomedical References

Search PubMed

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: