Agent Name

Nitroarginine

CAS Number

2149-70-4

Formula

C6-H13-N5-O4

Major Category

Biological Agents

Synonyms

Arginine, N(G)-nitro-; Arginine, omega-nitro-; Arginine, omega-nitro-, L-; L-NNA; N(G)-Nitro-L-arginine; N(G)-Nitroarginine; N(sup G)-Nitro-L-arginine; Nitro-L-arginine; Norvaline, 5-(2-nitroguanidino)-, (+)-; omega-Nitroarginine; Ornithine, N(5)-(nitroamidino)-, L-; L-Ornithine, N5-(imino(nitroamino)methyl)-; NG-Nitro-L-arginine; [ChemIDplus] L-NG-Nitroarginine; N(Sup 5)-(imino(nitroamino)methyl)-L-ornithine; N(sup gamma)-Nitro-L-arginine; NG-Nitroarginine; NOLA; Ornithine, N(sup 5)-(nitroamidino)-, L- (8CI); omega-Nitro-L-arginine; [RTECS] N-omega-Nitro-L-arginine; [Sigma-Aldrich MSDS]

Category

Amino Acids and Derivatives

Description

White powder; [Sigma-Aldrich MSDS]

Sources/Uses

"An inhibitor of nitric oxide synthetase which has been shown to prevent glutamate toxicity. Nitroarginine has been experimentally tested for its ability to prevent ammonia toxicity and ammonia-induced alterations in brain energy and ammonia metabolites. (Neurochem Res 1995:200(4):451-6)" [ChemIDplus]

Comments

Causes rigidity and inflammation in acute intraperitoneal studies of mice; Causes changes to glomeruli and brain in repeated-dose oral studies of rats; [RTECS] Not considered hazardous by GHS classification; [Sigma-Aldrich MSDS] See "Arginine."

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