Agent Name

Methyl acrylate

Alternative Name

Acrylic acid, methyl ester

CAS Number

96-33-3

Formula

C4-H6-O2

Major Category

Plastics & Rubber

Synonyms

Methoxycarbonylethylene; Methyl ester of acrylic acid; Methyl propenoate; Acrylic acid, methyl ester; [NIOSH]

Category

(Meth)acrylates

Description

Colorless liquid with an acrid odor; [NIOSH]

Sources/Uses

Acrylates and methacrylates are monomers that are combined with other monomers or polymers to produce plastics used in cosmetics, medicine, dentistry, and manufacturing industries. [Marks, p. 181] Workers in dental and surgical laboratories may be exposed; Used as a comonomer with acrylonitrile to produce acrylic and modacrylic fibers to make clothing and home furnishings; Also used to prepare paperboard, thermoplastic coatings, adhesives, sealants, surfactants, medical and dental prostheses, contact lenses, latex coatings, fabric finishes, and resins for purification of industrial effluents; [ACGIH]

Comments

Lethal concentrations are 237 ppm in rabbits and guinea pigs and 578 ppm in rats with animals showing dyspnea, convulsions, and microscopic evidence of pulmonary congestion. [ACGIH] Liquid causes first degree burns on short exposure. [CHRIS] "Repeated or prolonged contact may cause skin sensitization." [ICSC] A lachrymator; [CHEMINFO] Methyl acrylate, stabilized (UN1919) has warning of explosive polymerization; [ERG 2016]

Exposure Assessment
Skin Designation (ACGIH)

Yes

TLV (ACGIH)

2 ppm

PEL (OSHA)

10 ppm

MAK

2 ppm

IDLH (NIOSH)

250 ppm

Excerpts from Documentation for IDLHs

Other animal data: Rats exposed 4 hours per day, 5 days per week at 110 ppm for a total of 32 exposures had eye discomfort at the start of the investigation, but no overt signs of respiratory distress or other manifestations of toxicity were recorded [Oberly and Tansey 1985].

Vapor Pressure

65 mm Hg

Odor Threshold Low

0.003 ppm

Odor Threshold High

0.02 ppm

Lethal Concentration

LC50 (rat) = 1,350 ppm/4H

Explosive Polymerization

Yes

Explanatory Notes

Odor threshold from AIHA;

Reference Link

ICSC: Methyl acrylate

Adverse Effects
Skin Sensitizer

Yes

Lacrimator

Yes

Toxic Pneumonitis

Yes

Dermatotoxin

Skin Burns

IARC Carcinogen

Not Classifiable

ACGIH Carcinogen

Not Classifiable

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

Search ChemIDplus

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: