Agent Name

p-Phenetidine

CAS Number

156-43-4

Formula

C8-H11-N-O

Major Category

Nitrogen Compounds

Synonyms

Ethyl p-aminophenol; Phenetidine; 1-Amino-4-ethoxybenzene; 4-Aminoethoxybenzene; 4-Aminophenetole; 4-Ethoxyaniline; 4-Ethoxybenzenamine; Aniline, p-ethoxy-; CP 5685; p-Aminofenetol [Czech]; p-Aminophenetole; p-Ethoxyaniline; p-Fenetidin [Czech]; p-Phenetidin; Benzenamine, 4-ethoxy-; [ChemIDplus] p-Aminophenyl ethyl ether; [Merck Index] 4-Amino-1-ethoxy benzene; [ICSC] 4-Ethoxyphenylamine; para-Aminoethoxybenzene; para-Phenetidine; 4-Phenetidine; [CAMEO] 1-AMINO-4-ETHOXYBENZOL; 4-AMINO-1-ETHOXYBENZOL; 4-AMINOPHENOLETHYLETHER; 4-AMINOPHENYLETHYLETHER; 4-ETHOXYANILIN; 4-PHENETIDIN; P-AMINOPHENETOL; [IUCLID] UN2311

Category

Amines, Aromatic

Description

Colorless liquid; Turns red to brown on air and light exposure; [Merck Index] Brown liquid with an unpleasant odor; [Alfa Aesar MSDS]

Sources/Uses

Used to make acetophenetidine, phenocoll, dulcin, and dyes; [Merck Index] Used to make fine chemicals; [ExPub: ECHA REACH Registrations]

Comments

An eye irritant; May induce methemoglobinemia; [ICSC] Causes methemoglobinemia in repeated-dose oral studies of rats; [RTECS] Toxic by ingestion, inhalation, and skin absorption; May cause contact irritation, cyanosis, hypothermia, headache, drowsiness, vomiting, nephritis, and alimentary tract irritation; [NTP] Case report of methemoglobinemia from occupational exposure; Sensitizing in 2 of 3 maximization tests of guinea pigs; Not a lung sensitizer in guinea pigs; Some evidence of skin sensitization in humans; [IUCLID] A strong eye irritant; May cause skin sensitization; Harmful by ingestion, inhalation, and skin absorption; Suspected mutagen; [Alfa Aesar MSDS] See "m-Phenetidine." See "p-Anisidine."

Exposure Assessment
Vapor Pressure

0.01 mm Hg

Lethal Concentration

LCLo (rat) = 487 mg/m3/4hr

Explanatory Notes

LC50 (rat) = 3,530 mg/m3/4hr; [IUCLID] The Guide in the Emergency Response Guidebook is for "Phenetidines."

Flammability (NFPA)

1: Must be preheated

Adverse Effects
Skin Sensitizer

Yes

Methemoglobinemia

Methemoglobinemia, Secondary

Links to Other NLM Databases
Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: