Agent Name

Methyl methacrylate

CAS Number

80-62-6

Formula

C5-H8-O2

Major Category

Plastics & Rubber

Synonyms

Methacrylate monomer; Methyl ester of methacrylic acid; Methyl-2-methyl-2-propenoate; [NIOSH] 2-Methyl-2-propenoic acid methyl ester; MMA; [ACGIH]

Category

(Meth)acrylates

Description

Colorless liquid with an acrid, fruity odor; [NIOSH]

Sources/Uses

Acrylates and methacrylates are monomers that are combined with other monomers or polymers to produce plastics used in cosmetics, medicine, dentistry, and manufacturing industries. [Marks, p. 181] Occupational asthma in operating room nurse; [Malo] Used to make Lucite, Plexiglas, paper coatings, latex paints, inks, polishes, dental restorations, adhesive cements, surgical implants, and impregnated concrete; [ACGIH]

Comments

"MMA is an ocular and upper respiratory tract irritant, and it is a skin sensitizer and a suspected respiratory sensiitizer." [ACGIH] Liquid causes first degree burns on short exposure. [CHRIS] Can cause occupational asthma; [Reference #1] The highest exposures to the monomer occur in workers who use the monomer to manufacture other products with lower exposures in workers who produce the monomer. [Reference #2] Dentists are exposed to a median 8-hour time weighted average of 0.8 ug/m3. [PMID 16020090]

Restricted

In the mid-1970s it was banned by the FDA for use in nail preparations. It was replaced by ethyl methacrylate which also caused sensitization. [Marks, p. 181-2]

Reference Link

Occupational asthma due to methyl methacrylate and cyanoacrylates

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

TLV (ACGIH)

50 ppm

STEL (ACGIH)

100 ppm

PEL (OSHA)

100 ppm

MAK

50 ppm

IDLH (NIOSH)

1000 ppm

Vapor Pressure

40 mm Hg

Odor Threshold Low

0.01 ppm

Odor Threshold High

0.46 ppm

Lethal Concentration

LC50 (rat) = 78,000 mg/m3/4H

Explanatory Notes

Detection odor threshold from AIHA (mean = 0.049 ppm);

Reference Link

A cross-industry assessment of personal exposures ...[J Occup Environ Hyg. 2008] - PubMed Result

Flammability (NFPA)

3: May ignite at ambient temperature

Adverse Effects
Skin Sensitizer

Yes

Asthma

Yes

Dermatotoxin

Skin Burns

IARC Carcinogen

Not Classifiable

ACGIH Carcinogen

Not Classifiable

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Biomedical References

Search PubMed

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure:

Activities

Activities with risk of exposure: