Agent Name

p-Toluenesulfonyl isocyanate

CAS Number

4083-64-1

Formula

C8-H7-N-O3-S

Major Category

Nitrogen Compounds

Synonyms

Benzenesulfonyl isocyanate, 4-methyl-; p-Toluenesulphonyl isocyanate; p-Toluenesulfonic acid, anhydride with isocyanic acid; [ChemIDplus] PTSI; [EPA ChAMP: Submission] Additive TI; Isocyanic acid, anhydride with p-toluenesulfonic acid (6CI); p-Methylbenzenesulfonyl isocyanate; 4-Methylbenzenesulfonyl isocyanate; p-Methylphenylsulfonyl isocyanate; 4-Methylphenylsulfonyl isocyanate; 4-Toluenesulfonyl isocyanate; Tosyl isocyanate; p-Tosyl isocyanate; [RTECS] UN2206

Category

Other Aromatics (Nitrogen)

Description

Colorless liquid with an irritating odor; [Alfa Aesar MSDS]

Sources/Uses

Used in polyurethane coatings, sealants, and adhesives, as a stabilizer for organic isocyanates, and as a chemical intermediate; [EPA ChAMP: Submission] Used to formulate adhesives-sealants and paints-coatings-thinners and as an intermediate for pharmaceuticals; [ExPub: ECHA REACH Registrations]

Comments

A mild skin and moderate eye irritant; Causes changes in leukocyte count and changes in liver and kidney weights in 42-day constant oral studies of rats; [RTECS] Highly reactive; Hydrolyses rapidly forming p-toluenesulfonamide (CAS# 70-55-3) and carbon dioxide; [EPA ChAMP: Submission] Reacts violently with water; A skin and strong eye irritant; May cause respiratory sensitization; [Alfa Aesar MSDS] Search for (4083-64-1[EC/RN Number]) AND (asthma OR dermatitis OR allergic OR sensitizer OR sensitization): no results; [PubMed] See "p-Toluenesulfonamide."

Exposure Assessment
Lethal Concentration

LC50 (rat) > 640 ppm/1hr

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Isocyanates, toxic, n.o.s."

Links to Other NLM Databases
Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Related Information in HazMap
Processes

Industrial Processes with risk of exposure: