Agent Name

Toluene diisocyanate

Alternative Name

TDI

CAS Number

26471-62-5

Formula

C9-H6-N2-O2

Major Category

Plastics & Rubber

Synonyms

1,3-Diisocyanatomethylbenzene; 2,4/2,6-Toluene diisocyanate isomeric mixture; Benzene, 1,3-diisocyanatomethyl-; Diisocyanatotoluene; Isocyanic acid, methyl-m-phenylene ester; Methyl-m-phenylene isocyanate; Methyl-meta-phenylene diisocyanate; Methylphenylene isocyanate; Nacconate-100; Niax isocyanate TDI; Rubinate TDI; Rubinate TDI 80/20; TDI; TDI 80-20; Tolylene diisocyanate; Tolylene isocyanate; m-Tolylidene diisocyanate; 2,4- and 2,6-Toluene diisocyanate; Toluene-2,4-diisocyanate (mixt. With Toluene-2,6-diisocyanate); Toluenediisocyanate (mixed isomers); [ChemIDplus] VORANATE T-80 Type I TDI; [Dow Chemical MSDS] UN2068

Category

Diisocyanates

Description

Clear colorless to pale yellow liquid with a pungent odor; [HSDB] Colorless to yellow liquid with a sharp odor; mp = 14 deg C; [Dow Chemical MSDS]

Sources/Uses

Used to make polyurethanes, polyurethane foams, elastomers, and coatings, as a cross-linker for nylon-6, and hardener for adhesives and finishes; [HSDB]

Comments

Most commonly produced as a mixture of isomers, with 80% 2,4- and 20% 2,6-isomers; Also available as a mixture of 65% 2,4- and 35% 2,6-isomers; [HSDB] This CAS# is for mixture of toluene-2,4-diisocyanate and toluene-2,6-diisocyanate; Reacts slowly with water evolving carbon dioxide; An irritant; May cause skin and respiratory sensitization; Excessive inhalation exposure may cause severe irritation, pulmonary edema, permanently decreased lung function, neurologic disorders, cholinesterase depression, and gastrointestinal distress; [Dow Chemical MSDS] See "Toluene-2,4-diisocyanate" and "Toluene 2,6-diisocyanate."

Exposure Assessment
BEI

Toluene diamine in urine at end of shift = 5 ug/g creatine; [TLVs and BEIs]

Skin Designation (ACGIH)

Insufficient data

TLV (ACGIH)

0.001 ppm, inhalable fraction and vapor

STEL (ACGIH)

0.005 ppm, inhalable fraction and vapor

PEL (OSHA)

Ceiling(OSHA) = 0.02 ppm

Vapor Pressure

0.02 mm Hg

Odor Threshold Low

0.05 ppm

Lethal Concentration

LC50 (mouse) = 9.7 ppm/4hr

Explanatory Notes

No major toxicological differences between the various isomers and commercial mixtures of TDI; TLV Basis: asthma; pulmonary function; eye irritation; [ACGIH]

Flammability (NFPA)

1: Must be preheated

Adverse Effects
Skin Sensitizer

Yes

Asthma

Yes

Toxic Pneumonitis

Yes

Fibrogenic

Yes

Dermatotoxin

Skin Burns

IARC Carcinogen

Possible Carcinogen

NTP Carcinogen

Anticipated Human Carcinogen

Links to Other NLM Databases
Health Studies

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Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: