Agent Name

Saxitoxin

CAS Number

35523-89-8

Formula

C10-H17-N7-O4

Major Category

Biological Agents

Synonyms

Gonyaulax catenella poison; Mytilus californianus poison; Saxidomus giganteus poison; Saxitoxin hydrate; 1H,10H-Pyrrolo(1,2-c)purine-10,10-diol, 2,6-diamino-4-(((aminocarbonyl)oxy)methyl)-3a,4,8,9-tetrahydro-, (3aS-(3a-alpha,4-alpha,10aR*)); 1H,10H-Pyrrolo(1,2-c)purine-10,10-diol, 2,6-diamino-4-(((aminocarbonyl)oxy)methyl)-3a,4,8,9-tetrahydro-, (3aS,4R,10aS)-; [ChemIDplus] (3aS,4R,10aS)-2,6-Diamino-4-[[(aminocarbonyl)oxy]methyl]-3a,4,8,9-tetrahydro-1H,10H-pyrrolo[1,2-c]purine-10,10-diol; Mussel poison; Clam poison; Paralytic shellfish poison; Gonyaulax toxin; STX; [Merck Index] UN3462

Category

Seafood Toxins

Description

Solid; [Sigma-Aldrich MSDS]

Sources/Uses

Potent neurotoxin made by dinoflagellates in the Gonyaulax genus; Causes shellfish poisoning in humans; [Merck Index]

Comments

Causes flaccid paralysis without anesthesia (usually neuromuscular blockage) in oral lethal-dose studies of mice, rats, rabbits, cats, and dogs; [RTECS] Symptoms of severe poisoning include paresthesia, muscle weakness, vertigo, cranial nerve dysfunction, respiratory failure, and death; [CDC] May cause irritation; Highly toxic by ingestion, inhalation, and skin absorption; Targets nerves; [Sigma-Aldrich MSDS] See "Saxitoxin dihydrochloride."

Exposure Assessment
Lethal Concentration

LC50 (mouse) = 0.3 mg/m3/24hr

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Toxins, extracted from living sources, solid, n.o.s."

Adverse Effects
Neurotoxin

Other CNS Neurotoxin

Links to Other NLM Databases
Toxicity Information

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Chemical Information

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Related Information in HazMap
Other Information

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