Agent Name

Spermine

CAS Number

71-44-3

Formula

C10-H26-N4

Major Category

Biological Agents

Synonyms

1,4-Bis(aminopropyl) butanediamine; 1,4-Bis(aminopropyl)butanediamine; 1,4-Diaminobutane, N,N'-bis(3-aminopropyl)-; 4,9-Diaza-1,12-dodecanediamine; Diaminopropyltetramethylenediamine; Gerontine; Musculamine; N,N'-Bis(3-aminopropyl)-1,4-butanediamine; Neuridine; Spermin; Spermina [Italian]; Spermine, puriss; 1,4-Butanediamine, N,N'-bis(3-aminopropyl)-; 1,4-Butanediamine, N1,N4-bis(3-aminopropyl)-; 4,9-Diazadodecamethylenediamine; [ChemIDplus] N1,N4-Bis(3-aminopropyl)-1,4-butanediamine; N,N'-Bis(3-aminopropyl)tetramethylenediamine; [Merck Index] N,N'-Bis(3-aminopropyl)-1,4-tetramethylenediamine; [RTECS] UN3259

Category

Amino Acids and Derivatives

Description

Solid; Absorbs carbon dioxide from air; [Merck Index] Colorless solidified mass or fragments; mp = 28-30 deg C; [Sigma-Aldrich MSDS]

Sources/Uses

Used as a tool in biochemical research; [Merck Index] "Spermine is a polyamine involved in cellular metabolism found in all eukaryotic cells. The precursor for synthesis of spermine is the amino acid ornithine. It is found in a wide variety of organisms and tissues and is an essential growth factor in some bacteria." [Wikipedia]

Comments

Corrosive; [Merck Index] Oral LD30 (mouse) = 650 mg/kg; Causes lung changes, renal tubular changes, and dehydration in intraperitoneal lethal-dose studies of rats; Causes somnolence and convulsions in oral and subcutaneous lethal-dose studies of mice; Causes hypoglycemia and effects on enzymes and lipids in repeated-dose oral studies of rats; [RTECS] Causes burns; Inhalation may cause corrosive injuries to upper respiratory tract; [Sigma-Aldrich MSDS]

Exposure Assessment
Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Polyamines, solid, corrosive, n.o.s."

Adverse Effects
Dermatotoxin

Skin Burns

Links to Other NLM Databases
Toxicity Information

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Chemical Information

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Related Information in HazMap
Other Information

No other related information on this agent was found.