Agent Name

Acetophenone

CAS Number

98-86-2

Formula

C8-H8-O

Major Category

Other Classes

Synonyms

1-Phenyl-1-ethanone; 1-Phenylethanone; Acetofenon [Czech]; Acetophenon; Acetylbenzene; Acetylbenzol; Benzene, acetyl-; Benzoyl methide; Benzoylmethide; Ethanone, 1-phenyl-; Hypnone; Ketone, methyl phenyl; Methyl phenyl ketone; Phenyl methyl ketone; USAF EK-496; [ChemIDplus] UN 1993

Category

Aromatic Ketones

Description

Liquid that forms crystals at low temperature; [Merck Index]

Sources/Uses

Used in textile coatings; [Olson, p. 661] Used in perfumes for orange blossom odor; Also used in organic synthesis and as a polymerization catalyst for olefins; [Merck Index] Used in the past as an analgesic and anesthetic; [ACGIH] Used as a solvent in plastics and resins and a flavoring agent in foods; [HSDB]

Comments

A skin and eye irritant; Can cause CNS depression at high concentrations; [Olson, p. 661] Inhalation of high concentration can cause unconsciousness; [ICSC] In rats, the lethal concentration is >210 ppm for 8 hours; In mice, the lethal concentration (LC50) is 1200 mg/m3/4H (244 ppm/4H); [RTECS] TLV Basis: Irritation, CNS impairment; Pregnancy loss; [ACGIH]

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

TLV (ACGIH)

10 ppm

WEEL

10 ppm

Vapor Pressure

0.39 mm Hg

Odor Threshold Low

0.17 ppm

Odor Threshold High

0.6 ppm

RD50

100 ppm

Lethal Concentration

LC (rat) = >210 ppm/8h

Explanatory Notes

Odor Threshold avg = 0.5 ppm. [CHEMINFO] mp = 20.5 deg C; bp = 202 deg C; Flash point = 105 deg C; [Merck Index]

Adverse Effects
Neurotoxin

CNS Solvent Syndrome

Reproductive Toxin

Yes

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: