| Agent Name | Acetophenone |
|---|---|
| CAS Number | 98-86-2 |
| Formula | C8-H8-O |
| Major Category | Other Classes |
| Synonyms | 1-Phenyl-1-ethanone; 1-Phenylethanone; Acetofenon [Czech]; Acetophenon; Acetylbenzene; Acetylbenzol; Benzene, acetyl-; Benzoyl methide; Benzoylmethide; Ethanone, 1-phenyl-; Hypnone; Ketone, methyl phenyl; Methyl phenyl ketone; Phenyl methyl ketone; USAF EK-496; [ChemIDplus] UN 1993 |
| Category | Aromatic Ketones |
| Description | Liquid that forms crystals at low temperature; [Merck Index] |
| Sources/Uses | Used in textile coatings; [Olson, p. 661] Used in perfumes for orange blossom odor; Also used in organic synthesis and as a polymerization catalyst for olefins; [Merck Index] Used in the past as an analgesic and anesthetic; [ACGIH] Used as a solvent in plastics and resins and a flavoring agent in foods; [HSDB] |
| Comments | A skin and eye irritant; Can cause CNS depression at high concentrations; [Olson, p. 661] Inhalation of high concentration can cause unconsciousness; [ICSC] In rats, the lethal concentration is >210 ppm for 8 hours; In mice, the lethal concentration (LC50) is 1200 mg/m3/4H (244 ppm/4H); [RTECS] TLV Basis: Irritation, CNS impairment; Pregnancy loss; [ACGIH] |
| Exposure Assessment | |
| Skin Designation (ACGIH) | Insufficient data |
| TLV (ACGIH) | 10 ppm |
| WEEL | 10 ppm |
| Vapor Pressure | 0.39 mm Hg |
| Odor Threshold Low | 0.17 ppm |
| Odor Threshold High | 0.6 ppm |
| RD50 | 100 ppm |
| Lethal Concentration | LC (rat) = >210 ppm/8h |
| Explanatory Notes | Odor Threshold avg = 0.5 ppm. [CHEMINFO] mp = 20.5 deg C; bp = 202 deg C; Flash point = 105 deg C; [Merck Index] |
| Adverse Effects | |
| Neurotoxin | CNS Solvent Syndrome |
| Reproductive Toxin | Yes |
| Links to Other NLM Databases | |
| Health Studies | Human Health Effects from Hazardous Substances Data Bank: |
| Toxicity Information | |
| Chemical Information | |
| Related Information in HazMap | |
| Diseases | Occupational diseases associated with exposure to this agent: |
| Processes | Industrial Processes with risk of exposure: |
Agent Name
Acetophenone
CAS Number
98-86-2
Formula
C8-H8-O
Major Category
Other Classes
Synonyms
1-Phenyl-1-ethanone; 1-Phenylethanone; Acetofenon [Czech]; Acetophenon; Acetylbenzene; Acetylbenzol; Benzene, acetyl-; Benzoyl methide; Benzoylmethide; Ethanone, 1-phenyl-; Hypnone; Ketone, methyl phenyl; Methyl phenyl ketone; Phenyl methyl ketone; USAF EK-496; [ChemIDplus] UN 1993
Category
Aromatic Ketones
Description
Liquid that forms crystals at low temperature; [Merck Index]
Sources/Uses
Used in textile coatings; [Olson, p. 661] Used in perfumes for orange blossom odor; Also used in organic synthesis and as a polymerization catalyst for olefins; [Merck Index] Used in the past as an analgesic and anesthetic; [ACGIH] Used as a solvent in plastics and resins and a flavoring agent in foods; [HSDB]
Comments
A skin and eye irritant; Can cause CNS depression at high concentrations; [Olson, p. 661] Inhalation of high concentration can cause unconsciousness; [ICSC] In rats, the lethal concentration is >210 ppm for 8 hours; In mice, the lethal concentration (LC50) is 1200 mg/m3/4H (244 ppm/4H); [RTECS] TLV Basis: Irritation, CNS impairment; Pregnancy loss; [ACGIH]
Exposure Assessment
Skin Designation (ACGIH)
Insufficient data
TLV (ACGIH)
10 ppm
WEEL
10 ppm
Vapor Pressure
0.39 mm Hg
Odor Threshold Low
0.17 ppm
Odor Threshold High
0.6 ppm
RD50
100 ppm
Lethal Concentration
LC (rat) = >210 ppm/8h
Explanatory Notes
Odor Threshold avg = 0.5 ppm. [CHEMINFO] mp = 20.5 deg C; bp = 202 deg C; Flash point = 105 deg C; [Merck Index]
Adverse Effects
Neurotoxin
CNS Solvent Syndrome
Reproductive Toxin
Yes
Links to Other NLM Databases
Toxicity Information
Chemical Information
Related Information in HazMap
Processes
Industrial Processes with risk of exposure: