Agent Name | Acetophenone |
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CAS Number | 98-86-2 |
Formula | C8-H8-O |
Major Category | Other Classes |
Synonyms | 1-Phenyl-1-ethanone; 1-Phenylethanone; Acetofenon [Czech]; Acetophenon; Acetylbenzene; Acetylbenzol; Benzene, acetyl-; Benzoyl methide; Benzoylmethide; Ethanone, 1-phenyl-; Hypnone; Ketone, methyl phenyl; Methyl phenyl ketone; Phenyl methyl ketone; USAF EK-496; [ChemIDplus] UN 1993 |
Category | Aromatic Ketones |
Description | Liquid that forms crystals at low temperature; [Merck Index] |
Sources/Uses | Used in textile coatings; [Olson, p. 586] Used in perfumes for orange blossom odor; Also used in organic synthesis and as a polymerization catalyst for olefins; [Merck Index] Used in the past as an analgesic and anesthetic; [ACGIH] Used as a solvent in plastics and resins and a flavoring agent in foods; [HSDB] |
Comments | A skin and eye irritant; Can cause CNS depression at high concentrations; [Olson, p. 586] Inhalation of high concentration can cause unconsciousness; [ICSC] In rats, the lethal concentration is >210 ppm for 8 hours; In mice, the lethal concentration (LC50) is 1200 mg/m3/4H (244 ppm/4H); [RTECS] TLV Basis: Irritation, CNS impairment; Pregnancy loss; [ACGIH] |
Exposure Assessment | |
Skin Designation (ACGIH) | Insufficient data |
TLV (ACGIH) | 10 ppm |
WEEL | 10 ppm |
Vapor Pressure | 0.39 mm Hg |
Odor Threshold Low | 0.17 ppm |
Odor Threshold High | 0.6 ppm |
RD50 | 100 ppm |
Lethal Concentration | LC (rat) = >210 ppm/8h |
Explanatory Notes | Odor Threshold avg = 0.5 ppm. [CHEMINFO] mp = 20.5 deg C; bp = 202 deg C; Flash point = 105 deg C; [Merck Index] |
Adverse Effects | |
Neurotoxin | CNS Solvent Syndrome |
Reproductive Toxin | Yes |
Links to Other NLM Databases | |
Health Studies | Human Health Effects from Hazardous Substances Data Bank: |
Toxicity Information | |
Chemical Information | |
Related Information in HazMap | |
Diseases | Occupational diseases associated with exposure to this agent: |
Processes | Industrial Processes with risk of exposure: |