Agent Name

MPTP

CAS Number

28289-54-5

Formula

C12-H15-N

Major Category

Nitrogen Compounds

Synonyms

1,2,3,6-Tetrahydro-1-methyl-4-phenylpyridine; 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; MPTP; N-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; [ChemIDplus]

Category

Pyridines

Description

Crystals; [HSDB]

Sources/Uses

A contaminant produced during the synthesis of MPPP, a synthetic heroin; it causes irreversible parkinsonism in primates and is used in research laboratories; MPTP is converted to the toxic metabolite MPP+ in the brain where it selectively destroys cells in the substantia nigra. [Merck Index #6294]

Comments

The toxic effects of MPTP were discovered in 1982 when several injection drug users in San Jose, California developed "frozen addict" syndrome within a week of using MPPP contaminated with MPTP. The syndrome resembled idiopathic Parkinson disease, and patients showed some improvement after treatment with L-dopa. [Ford, p. 634-5] MPTP does not cause occupational parkinsonism, but it causes acute parkinsonism in humans and experimental animals after injection. The cumulative doses in animals are in the range of 1.5 to 410 mg/kg depending on the species. [See Reference #1}

Reference Link

Animal models of Parkinson's disease: an empirical...[J Neural Transm. 1996] - PubMed Result

Exposure Assessment
Vapor Pressure

0.00945 mm Hg

Adverse Effects
Neurotoxin

Parkinson's Syndrome

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Other Information

No other related information on this agent was found.