Agent Name

Diethylamine

CAS Number

109-89-7

Formula

C4-H11-N

Major Category

Nitrogen Compounds

Synonyms

N,N-Diethylamine; N-Ethylethanamine; Diethamine; Ethanamine, N-ethyl; [CHEMINFO] UN1154

Category

Amines, Aliphatic

Description

Colorless liquid with a fishy, ammonia-like odor; [NIOSH]

Sources/Uses

Used in the manufacture of rubber, petroleum products, resins, dyes, and pharmaceuticals; [Merck Index] Used as a corrosion inhibitor, rubber accelerator, and polymerization inhibitor; Also used in electroplating and as an organic intermediate; A metabolite of the drug disulfiram used in the treatment of alcohol abuse; [ACGIH]

Comments

Diethylamine can cause necrosis to the skin. Rabbits exposed to 100 ppm, 7 hours/day, 5 days/week for 6 weeks have bronchopneumonia; [ACGIH] If left on clothing, can cause reddening of skin; [CHRIS] Corrosive to skin; [Quick CPC] Causes liver damage in high-dose animal studies; [HSDB] A corrosive substance that can cause pulmonary edema; [ICSC]

Exposure Assessment
Skin Designation (ACGIH)

Yes

TLV (ACGIH)

5 ppm

STEL (ACGIH)

15 ppm

PEL (OSHA)

25 ppm

MAK

2 ppm

IDLH (NIOSH)

200 ppm

Excerpts from Documentation for IDLHs

Human data: It has been stated that the simple alkyl amines are generally more toxic than ammonia [ACGIH 1991]. The American Conference of Governmental Industrial Hygienists TLV for diethylamine (10 ppm TWA, 25 ppm STEL) was based on an analogy to ammonia (25 ppm TWA, 35 ppm STEL) [ACGIH 1991].

Vapor Pressure

237 mm Hg

Odor Threshold Low

0.02 ppm

Odor Threshold High

14 ppm

RD50

184 ppm

Lethal Concentration

LC50 (rat) = 4,000 ppm/4H

Explanatory Notes

Detection odor threshold from AIHA (mean = 0.053 ppm); Flash point = -20 deg F;

Reference Link

ICSC: Diethylamine

Adverse Effects
Toxic Pneumonitis

Yes

Hepatotoxin

Hepatotoxin, Secondary

Dermatotoxin

Skin Burns

ACGIH Carcinogen

Not Classifiable

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Processes

Industrial Processes with risk of exposure: