Agent Name

Isopropylamine

CAS Number

75-31-0

Formula

C3-H9-N

Major Category

Nitrogen Compounds

Synonyms

1-Methylethylamine; 2-Amino-propaan [Dutch]; 2-Amino-propano [Italian]; 2-Aminopropan [German]; 2-Aminopropane; 2-Propanamine; 2-Propaneamine; 2-Propylamine; Isopropilamina [Italian]; Monoisopropylamine; Propanal, 2-amino-; Propane, 2-amino-; sec-Propylamine; [ChemIDplus] UN1221

Category

Amines, Aliphatic

Description

Colorless liquid with an ammonia-like odor; Note: A gas above 91 degrees F; [NIOSH]

Sources/Uses

Used as a solvent and as an intermediate in the synthesis of dyes, rubber additives, pesticides, surface active agents, and pharmaceuticals; [ACGIH]

Comments

Liquid causes first degree burns on short exposure. [CHRIS] Corrosive to skin; [Quick CPC] Acute animal toxicology studies indicate that inhaled isopropylamine has a potency about one half that of n-butylamine. It causes respiratory irritation, and can cause pulmonary edema. [ACGIH] May cause permanent eye injury; Transient visual effects ("blue haze" or "halo vision") occur at low concentrations; [CHEMINFO]

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

TLV (ACGIH)

5 ppm

STEL (ACGIH)

10 ppm

PEL (OSHA)

5 ppm

MAK

5 ppm

IDLH (NIOSH)

750 ppm

Excerpts from Documentation for IDLHs

Other animal data: It has been reported that rats have survived an exposure to 4,000 ppm for 4 hours [Smyth et al. 1951]. Human data: Volunteers have complained of nose and throat irritation after brief exposures to concentrations ranging from 10 to 20 ppm [Amoore and Hautala 1983].

Vapor Pressure

580 mm Hg

Odor Threshold Low

0.21 ppm

Odor Threshold High

0.7 ppm

Lethal Concentration

LC50 (rat) = 4,000 ppm/4H

Explanatory Notes

Detection odor threshold from AIHA (mean = 0.21 ppm); Flash point = -26 deg C;

Reference Link

ICSC: Isopropylamine

Adverse Effects
Toxic Pneumonitis

Yes

Dermatotoxin

Skin Burns

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Other Information

No other related information on this agent was found.