Agent Name

Diisopropylamine

CAS Number

108-18-9

Formula

C6-H15-N

Major Category

Nitrogen Compounds

Synonyms

2-Propanamine, N-(1-methylethyl)-; N-(1-Methylethyl)-2-propanamine; N-Isopropyl-1-amino-2-methylethane; [ChemIDplus] UN1158

Category

Amines, Aliphatic

Description

Colorless liquid with an ammonia- or fish-like odor; [NIOSH]

Sources/Uses

Used as a catalyst and chemical intermediate; [ACGIH] Many aliphatic amines are used as curing agents for epoxy resins. [Sullivan, p. 473]

Comments

Liquid causes first degree burns on short exposure; [CHRIS] Corrosive to skin; [Quick CPC] Diisopropylamine is a severe pulmonary irritant in acute and chronic animal studies. At concentrations of 25 to 50 ppm, workers have experienced transient corneal injury, nausea, and headache. [ACGIH] A corrosive substance that causes lacrimation and may cause lung edema after inhalation of high concentrations; [ICSC]

Exposure Assessment
Skin Designation (ACGIH)

Yes

TLV (ACGIH)

5 ppm

PEL (OSHA)

5 ppm

IDLH (NIOSH)

200 ppm

Excerpts from Documentation for IDLHs

Human data: Complaints of nausea, headache, and temporary dimness in vision were reported in workers 2 to 3 hours following several 5 to 10minute exposures to about 176 ppm; concentrations otherwise during the workshift averaged about 24 to 48 ppm [Treon et al. 1949].

Vapor Pressure

79.4 mm Hg

Odor Threshold Low

0.13 ppm

Lethal Concentration

LC50 (rat) = 4,800 mg/m3/2h

Explanatory Notes

Detection odor threshold from AIHA (mean = 0.13 ppm); Flash point = -1 deg C;

Reference Link

ICSC: Diisopropylamine

Flammability (NFPA)

3: May ignite at ambient temperature

Adverse Effects
Lacrimator

Yes

Toxic Pneumonitis

Yes

Dermatotoxin

Skin Burns

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Processes

Industrial Processes with risk of exposure: