Agent Name

Cyclohexylamine

CAS Number

108-91-8

Formula

C6-H13-N

Major Category

Nitrogen Compounds

Synonyms

1-Aminocyclohexane; 1-Cyclohexylamine; Aminocyclohexane; Aminohexahydrobenzene; Aniline, hexahydro-; Benzenamine, hexahydro-; CHA; Cyclohexanamine; Cyclohexylamine; Hexahydroaniline; Hexahydrobenzenamine; [ChemIDplus] UN2357

Category

Amines, Cyclic

Description

Colorless or yellow liquid with a strong, fishy, amine-like odor; [NIOSH]

Sources/Uses

Used to inhibit corrosion in boiler feed water and to manufacture "insecticides, plasticizers, dry-cleaning soaps, rubber chemicals, dye stuffs, and gas absorbents." [ACGIH]

Comments

Cyclohexylamine has moderate skin sensitizing potential and is a weak methemoglobin inducer. Listed in the table "Examples of Industrial Chemicals for Which Methemoglobin Formation is NOT the Principal Cause of Toxicity"; [ACGIH] Merck Index # 2729; Causes second and third degree burns after short skin exposure; [CHRIS] Corrosive to skin; [Quick CPC] Corrosive to the skin, eyes, and respiratory tract; Inhalation of high concentrations may cause CNS effects; [ICSC] No apparent effects in workers exposed to 4-10 ppm; Inhalation of high concentrations could cause pulmonary edema; A 25% solution produced severe irritation of the skin in humans; May cause permanent eye injury; Transient visual effects ("blue haze" or "halo vision") occur at low concentrations; [CHEMINFO]

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

TLV (ACGIH)

10 ppm

MAK

2 ppm

Vapor Pressure

10.1 mm Hg

Odor Threshold Low

2.6 ppm

Odor Threshold High

110 ppm

Lethal Concentration

LC50 (rat) = 7,500 mg/m3

Explanatory Notes

Flash point = 88 deg F; Odor thresholds from CHEMINFO;

Reference Link

ICSC: Cyclohexylamine

Adverse Effects
Skin Sensitizer

Yes

Toxic Pneumonitis

Yes

Methemoglobinemia

Methemoglobinemia, Secondary

Dermatotoxin

Skin Burns

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: