Agent Name

Cyclohexylamine

CAS Number

108-91-8

Formula

C6-H13-N

Major Category

Nitrogen Compounds

Synonyms

1-Aminocyclohexane; 1-Cyclohexylamine; Aminocyclohexane; Aminohexahydrobenzene; Aniline, hexahydro-; Benzenamine, hexahydro-; CHA; Cyclohexanamine; Cyclohexylamine; Hexahydroaniline; Hexahydrobenzenamine; [ChemIDplus] UN2357

Category

Amines, Cyclic

Description

Colorless or yellow liquid with a strong, fishy, amine-like odor; [NIOSH]

Sources/Uses

Used to inhibit corrosion in boiler feed water and to manufacture "insecticides, plasticizers, dry-cleaning soaps, rubber chemicals, dye stuffs, and gas absorbents." [ACGIH]

Comments

Cyclohexylamine has moderate skin sensitizing potential and is a weak methemoglobin inducer. Listed in the table "Examples of Industrial Chemicals for Which Methemoglobin Formation is NOT the Principal Cause of Toxicity"; [ACGIH] Merck Index # 2729; Causes second and third degree burns after short skin exposure; [CHRIS] Corrosive to skin; [Quick CPC] Corrosive to the skin, eyes, and respiratory tract; Inhalation of high concentrations may cause CNS effects; [ICSC] No apparent effects in workers exposed to 4-10 ppm; Inhalation of high concentrations could cause pulmonary edema; A 25% solution produced severe irritation of the skin in humans; May cause permanent eye injury; Transient visual effects ("blue haze" or "halo vision") occur at low concentrations; [CHEMINFO]

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

TLV (ACGIH)

10 ppm

MAK

2 ppm

Vapor Pressure

10.1 mm Hg

Odor Threshold Low

2.6 ppm

Odor Threshold High

110 ppm

Lethal Concentration

LC50 (rat) = 7,500 mg/m3

Explanatory Notes

Flash point = 88 deg F; Odor thresholds from CHEMINFO;

Reference Link

ICSC: Cyclohexylamine

Flammability (NFPA)

3: May ignite at ambient temperature

Adverse Effects
Skin Sensitizer

Yes

Toxic Pneumonitis

Yes

Methemoglobinemia

Methemoglobinemia, Secondary

Dermatotoxin

Skin Burns

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: