Agent Name

p-Phenylenediamine

CAS Number

106-50-3

Formula

C6-H8-N2

Major Category

Nitrogen Compounds

Synonyms

1,4-Diaminobenzene; 1,4-Phenylenediamine; 4-Aminoaniline; 6PPD; AI3-00710; BASF ursol D; Benzofur D; C.I. 76060; C.I. Developer 13; C.I. Oxidation Base 10; CI 76060; CI Developer 13; CI Oxidation Base 10; Developer 13; Developer PF; Durafur Black R; FUR Brown 41866; Fenylenodwuamina [Polish]; Fouramine D; Fourrine 1; Fourrine D; Fur Black 41866; Fur Black 41867; Fur Yellow; Furro D; Futramine D; Nako H; Orsin; Oxidation Base 10; PARA; Paraphenylen-diamine; Paraphenylenediamine; Pelagol D; Pelagol DR; Pelagol Grey D; Peltol D; Phenylenediamine; Renal PF; Rodol D; Santoflex IC; Santoflex LC; Tertral D; USAF EK-394; Ursol D; Vulkanox 4020; Zoba Black D; p-Aminoaniline; p-Benzenediamine; p-Diaminobenzene; p-Fenylendiamin [Czech]; p-Phenyldiamine; p-Phenylenediamine; UN1673; [ChemIDplus]

Category

Amines, Aromatic

Description

White to slightly red, crystalline solid; [NIOSH]

Sources/Uses

Used to dye hair and fur; also used to develop photographs and to synthesize other organic compounds; [ACGIH] Occupational asthma reported in fur dyers; [Malo] Allergic contact dermatitis in hairdressers, mechanics, printers, and textile workers; [Marks] Used to dye leather; [PMID 21938525]

Comments

An important dye used for permanent hair coloring, the dye itself (but not the dyed hair) can cause allergic contact dermatitis. [Marks, p. 111] Immunologic contact urticaria documented; [Kanerva, p. 219] In animal experiments, intraperitoneal injections induce methemoglobinemia, and chronic feeding causes fatty degeneration of the liver. Liver injury after occupational exposure has been reported. [ACGIH] Potential adverse effects include asthma, allergic contact dermatitis, methemoglobinemia, and kidney injury; [ICSC]

Reference Link

Allergic contact dermatitis on a violinist's neck from para-phenylenediamine in a chin rest stain

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

MAK

0.1 mg/m3

Excerpts from Documentation for IDLHs

Basis for revised IDLH: No inhalation toxicity data are available on which to base an IDLH for pphenylene diamine. Therefore, based on health considerations and acute oral toxicity data in animals [Burnett et al. 1977; Hanzlik 1923; Lloyd et al. 1977], a value of about 50 mg/m3 would have been appropriate. However, the revised IDLH for pphenylene diamine is 25 mg/m3 based on the concentration recommended originally in the Standards Completion Program for deciding when the "most protective" respirators should be used. Because sensitized workers may be affected by concentrations far below occupational exposure limits, exacerbation of asthma cannot be used to set an IDLH.

Vapor Pressure

0.005 mm Hg

Lethal Concentration

LC50 (rat) = 920 mg/m3/4H

Explanatory Notes

Flash point = 311 deg F;

Reference Link

ICSC: p-Phenylenediamine

Adverse Effects
Nephrotoxin

Yes

Skin Sensitizer

Yes

Asthma

Yes

Hepatotoxin

Hepatotoxin, Secondary

Methemoglobinemia

Methemoglobinemia, Secondary

Anemia

Anemia, Hemolytic

IARC Carcinogen

Not Classifiable

ACGIH Carcinogen

Not Classifiable

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: