Agent Name

Endrin

CAS Number

72-20-8

Formula

C12-H8-Cl6-O

Major Category

Pesticides

Synonyms

1,2,3,4,10,10-Hexachloro-6,7-epoxy-1,4,4a,5,6,7,8,8a-octahydro-1,4-endo,endo-5,8-dimethanonaphthalene; Hexadrin; [NIOSH]

Category

Organochlorine Pesticides

Description

Colorless to tan, crystalline solid with a mild, chemical odor. [insecticide]; [NIOSH]

Sources/Uses

Formerly used as an insecticide, as an avicide, and as a rodenticide; [HSDB]

Comments

High-dose animal studies show that organochlorine insecticides can cause liver injury. [LaDou, p. 593] "No evidence of hepatic injury in humans as the result of environmental contamination." [Zimmerman, p. 414]

Restricted

Voluntary cancellation in 1985; all U.S. registrations cancelled; [EPA Pesticides, p. 56]

Exposure Assessment
Skin Designation (ACGIH)

Yes

Bioaccumulates

Yes

TLV (ACGIH)

0.1 mg/m3

PEL (OSHA)

0.1 mg/m3

MAK

0.05 mg/m3, inhalable fraction

IDLH (NIOSH)

2 mg/m3

Excerpts from Documentation for IDLHs

Human data: An oral dose of 171 mg/kg has been reported to be lethal [Runhaar et al. 1985]. It has also been reported that the approximate oral dose producing convulsions is about 0.2 mg/kg [Hayes 1982]. [Note: Oral doses of 171 mg/kg or 0.2 mg/kg are equivalent to a 70kg worker being exposed to about 8,000 mg/m3 or 9 mg/m3, respectively, for 30 minutes, assuming a breathing rate of 50 liters per minute and 100% absorption.]

Vapor Pressure

3.0E-6 mm Hg

Half Life

No reports found; [TDR, p. 613]

Reference Link

ATSDR - ToxFAQs - Endrin

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

Other Poison

Organochlorine Pesticide

IARC Carcinogen

Not Classifiable

ACGIH Carcinogen

Not Classifiable

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: