Agent Name

Heptachlor

CAS Number

76-44-8

Formula

C10-H5-Cl7

Major Category

Pesticides

Synonyms

1,4,5,6,7,8,8-Heptachloro-3a,4,7,7a-tetrahydro-4,7-methanoindene; Biarbinex; Cupincida; Drinox; E 3314; Fennotox; Heptagran; Heptamul; Heptox; Termide; Velsicol 104.

Category

Organochlorine Pesticides

Description

White to light-tan crystals with a camphor-like odor. [insecticide]; [NIOSH]

Sources/Uses

Used to kill termites, ants, and soil insects; [EXTOXNET]

Comments

High-dose animal studies show that organochlorine insecticides can cause liver injury. [LaDou, p. 593] "No evidence of hepatic injury in humans as the result of environmental contamination." [Zimmerman, p. 414] Heptachlor exposure has been associated with aplastic anemia, e.g., after domestic application for termite control, but no dose-dependent relationship was found; [ACGIH] TLV basis = liver damage; Heptachlor epoxide (1024-57-3) is apparently formed during the environmental degradation of heptachlor. [ACGIH]

Restricted

All uses cancelled in 1988; still licensed for control of fire ants in electrical transformers; [EXTOXNET] All U.S. registrations cancelled except for underground use in power lines to control fire ants; [EPA Pesticides, p. 56]

Reference Link

EXTOXNET PIP - HEPTACHLOR

Exposure Assessment
Skin Designation (ACGIH)

Yes

Bioaccumulates

Yes

TLV (ACGIH)

0.05 mg/m3

PEL (OSHA)

0.5 mg/m3

MAK

0.05 mg/m3, inhalable fraction

IDLH (NIOSH)

35 mg/m3

Vapor Pressure

0.0003 mm Hg

Half Life

Heptachlor is stored mainly in fatty tissue. It could be detected in experimental rats for up to 14 weeks after cessation of exposure. [EXTOXNET]

Reference Link

ATSDR - ToxFAQs - Heptachlor and Heptachlor Epoxide

Adverse Effects
Anemia

Anemia, Aplastic

Hepatotoxin

Hepatotoxin, Secondary

Other Poison

Organochlorine Pesticide

IARC Carcinogen

Possible Carcinogen

ACGIH Carcinogen

Confirmed Animal

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: