Agent Name

Chlordecone

Alternative Name

Kepone

CAS Number

143-50-0

Formula

C10-Cl10-O

Major Category

Pesticides

Synonyms

1,1a,3,3a,4,5,5,5a,5b,6-Decachlorooctahydro-1,3,4-metheno-2H-cyclobuta(cd)pentalen-2-one; 1,2,3,4,5,5,6,7,8,9,10,10-Dodecachlorooctahydro-1,3,4-metheno-2-cyclobuta(c,d)pentalone; 1,2,3,5,6,7,8,9,10,10-Decachloro(5.2.1.0(sup 2,6).0(sup 3,9).0(sup 5,8))decano-4-one; 1,3,4-Metheno-2H-cyclobuta(cd)pentalen-2-one, 1,1a,3,3a,4,5,5,5a,5b,6-decachlorooctahydro-; 2,3,3a,4,5,6,7,7a,8,8a-Decachloro-3a,4,7,7a-tetrahydro-4,7-methanoinden-1-one; Chlordecone; Ciba 8514; Clordecone; Compound 1189; Decachloro-1,3,4-metheno-2H-cyclobuta(cd)pentalen-2-one; Decachloroketone; Decachlorooctahydro-1,3,4-methano-2H-cyclobuta(cd)pentalen-2-one; Decachlorooctahydro-1,3,4-metheno-2H-cyclobuta(cd)pentalen-2-one; Decachloropentacyclo(5.2.1.0(2,6).0(3,9).0(5),(8))decan-4-one; Decachloropentacyclo(5.2.1.0(sup 2,6).0(sup 3,9).0(sup 5,8))decan-4-one; Decachloropentacyclo(5.3.0.0(sup 2,6).0(sup 4,10).0(sup 5,9))decan-3-one; Decachlorotetracyclodecanone; Decachlorotetrahydro-4,7-methanoindeneone; GC 1189; General chemicals 1189; Kepone; Kepone-2-one, decachlorooctahydro-; Merex; Perchloropentacyclo(5.3.0.0(2,6).0(3,9).0(4,8))decan-5-one; [ChemIDplus]

Category

Organochlorine Pesticides

Description

Tan to white, crystalline, odorless solid. [insecticide]; [NIOSH]

Sources/Uses

Formerly used as an insecticide; Base material for the manufacture of kelevan; [HSDB]

Comments

In the past, workers in a manufacturing plant developed "Kepone shakes" with tremor, weakness, and slurred speech. Abnormal liver function tests were also seen. [Sullivan, p. 1078-9] Workers had decreased sperm counts. There is strong positive data and limited negative data that chlordecone causes fetal loss in animals. [ATSDR Case Studies #29]

Restricted

In 1975 the sole manufacturer of Kepone in the U.S. was ordered to terminate production. [Sullivan, p. 1048-9]

Exposure Assessment
Bioaccumulates

Yes

Vapor Pressure

3.0E-7 mm Hg

Explanatory Notes

NIOSH REL = 0.001 mg/m3;

Reference Link

ATSDR - ToxFAQs - Mirex and Chlordecone

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

Reproductive Toxin

Yes

Other Poison

Organochlorine Pesticide

IARC Carcinogen

Possible Carcinogen

NTP Carcinogen

Anticipated Human Carcinogen

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: