Agent Name

Methoxychlor

CAS Number

72-43-5

Formula

C16-H15-Cl3-O2

Major Category

Pesticides

Synonyms

1,1'-(2,2,2-Trichloroethylidene)bis(4-methoxybenzene); 1,1,1-Trichlor-2,2-bis(4-methoxy-phenyl)-aethan [German]; 1,1,1-Trichloro-2,2-bis(4-methoxyphenyl)ethane; 1,1,1-Trichloro-2,2-bis(p-anisyl)ethane; 1,1,1-Trichloro-2,2-bis(p-methoxyphenyl)ethane; 1,1,1-Trichloro-2,2-di(4-methoxyphenyl)ethane; 1,1-Bis(p-methoxyphenyl)-2,2,2-trichloroethane; 2,2,2-Trichloro-1,1-bis(4-methoxyphenyl)ethane; 2,2-Bis(p-anisyl)-1,1,1-trichloroethane; 2,2-Bis(p-methoxyphenyl)-1,1,1-trichloroethane; 2,2-Di-(p-methoxyphenyl)-1,1,1-trichloroethane; 2,2-Di-p-anisyl-1,1,1-trichloroethane; 4,4-(2,2,2-Trichloroethylidene)dianisole; Chemform; DMDT; Dianisyl trichloroethane; Dianisyltrichlorethane; Dimethoxy-DDT; Ethane, 1,1,1-trichloro-2,2-bis(p-methoxyphenyl)-; Ethane, 2,2-bis(p-anisyl)-1,1,1-trichloro-; Higalmetox; Maralate; Marlate; Methoxcide; Methoxy-DDT; Methoxychlor; Methoxychlor 2 EC; Methoxychlor, technical; Methoxychlore [ISO-French]; Metoksychlor [Polish]; Metox; Mezox K; Moxie; OMS 466; p,p'-Dimethoxydiphenyltrichloroethane; p,p'-Dwumetoksydwufenylotrojchloroetan [Polish]; p,p'-Methoxychlor; [ChemIDplus]

Category

Organochlorine Pesticides

Description

Colorless to light-yellow crystals with a slight, fruity odor. [insecticide]; [NIOSH]

Sources/Uses

Used to kill insects on fruits, vegetables, and forest crops; used to kill parasites on cattle; [EXTOXNET]

Comments

Methoxychlor is classified as "practically nontoxic" with an LD50 of 5-6 gm/kg in rats. It does not accumulate in tissues of mammals, but is highly toxic to fish. It persists in the soil with a half-life estimate of 120 days. [EXTOXNET] High-dose animal studies show that organochlorine insecticides can cause liver injury. [LaDou, p. 593] "No evidence of hepatic injury in humans as the result of environmental contamination." [Zimmerman, p. 414]

Reference Link

EXTOXNET PIP - METHOXYCHLOR

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

Bioaccumulates

Yes

TLV (ACGIH)

10 mg/m3

PEL (OSHA)

15 mg/m3, total dust

MAK

1 mg/m3, inhalable fraction

IDLH (NIOSH)

5000 mg/m3

Vapor Pressure

2.58E-6 mm Hg

Half Life

Animal studies: most of dose eliminated within a few days;; [TDR, p. 837]

Reference Link

ATSDR - ToxFAQs - Methoxychlor

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

Other Poison

Organochlorine Pesticide

IARC Carcinogen

Not Classifiable

ACGIH Carcinogen

Not Classifiable

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

Search ChemIDplus

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: