Agent Name

Nitroblue tetrazolium

CAS Number

298-83-9

Formula

C40-H30-N10-O6.2Cl

Major Category

Dyes

Synonyms

NBT; NBT (dye); Nitro BT; Nitro Blue tetrazolium; Nitro Blue tetrazolium chloride; Nitro Blue tetrazolium salt; Nitro tetrazolium BT; Nitroblue tetrazolium salt; Nitrotetrazolium Blue; Nitrotetrazolium Chloride Blue; Tetrazolium Nitro Blue; Tetrazolium nitro BT; p-Nitro Blue tetrazolium; p-Nitro Blue tetrazolium chloride; p-Nitrotetrazolium Blue; 2H-Tetrazolium, 2,2'-(3,3'-dimethoxy(1,1'-biphenyl)-4,4'-diyl)bis(3-(4-nitrophenyl)-5-phenyl-, chloride (1:2); 2H-Tetrazolium, 3,3'-(3,3'-dimethoxy(1,1'-biphenyl)-4,4'-diyl)bis(2-(4-nitrophenyl)-5-phenyl-, dichloride; 5,5'-Diphenyl-3,3'-bis(4-nitrophenyl)-2,2'-(3,3'-dimethoxybiphenyl-4,4'-ylene)ditetrazolium dichloride; [ChemIDplus]

Category

Other Dyes

Description

Solid; Color varies (colorless, yellow, blue or black); [ChemIDplus]

Sources/Uses

"Formerly used to distinguish between nonbacterial and bacterial diseases, the latter causing neutrophils to reduce the dye; used to confirm diagnosis of chronic granulomatous disease." [ChemIDplus] A microscopic stain used to detect dehydrogenases and alkaline phosphatase; [Ullmann]

Comments

May be harmful after ingestion, inhalation, or skin contact; A skin, eye, and respiratory tract irritant; Target organs are liver, heart, kidneys, and eyes. May cause convulsions; LD50 (mouse) = 2000 mg/kg; [MSDSonline] "Moderately toxic by ingestion." [Hawley]

Adverse Effects
Neurotoxin

Other CNS Neurotoxin

Hepatotoxin

Hepatotoxin, Secondary

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Chemical Information

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Other Information

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