Agent Name

18-Crown-6

CAS Number

17455-13-9

Formula

C12-H24-O6

Major Category

Other Classes

Synonyms

1,4,7,10,13,16-Hexanoxacyclooctadecane; 1,4,7,10,13,16-Hexaoxacyclooctadecane; 18-Crown-6; Ethylene oxide cyclic hexamer; [ChemIDplus]

Category

Other Organic Compounds

Description

Clear, odorless, hygroscopic liquid soluble in water and most organic solvents; [Ullmann] White crystals; [MSDSonline]

Sources/Uses

Drug/ Therapeutic Agent; [ChemIDplus] Used as complexing agents with ammonium ions and metal ions (alkali and alkaline-earth metals); Used as catalysts to make organic chemicals; [Ullmann]

Comments

If absorbed, can cause electrolyte imbalance affecting the CNS; Signs of intoxication include hyperventilation, tremor, incoordination, and CNS depression; May damage the skin and eyes; LD50 (mouse) by ingestion is 0.7 g/kg; LD50 (rabbit) by skin absorption is 200 mg/kg; [Ullmann] Toxic by ingestion; A skin, eye, and respiratory tract irritant; Oral LD50 (rat) = 525 mg/kg; Dermal LDLo (rat) = 7000 mg/kg; High-dose feeding causes seizures, weight loss, and liver injury in experimental animals; [MSDSonline]

Exposure Assessment
Vapor Pressure

6.67E-5 mm Hg

Explanatory Notes

mp = -38 deg C; bp = 116 deg C; [Ullmann] mp = 39-40 deg C; [MSDSonline]

Adverse Effects
Neurotoxin

Other CNS Neurotoxin

Hepatotoxin

Hepatotoxin, Secondary

Links to Other NLM Databases
Toxicity Information

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Chemical Information

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Related Information in HazMap
Other Information

No other related information on this agent was found.