Agent Name

Chlorpyrifos

Alternative Name

Dursban

CAS Number

2921-88-2

Formula

C9-H11-Cl3-N-O3-P-S

Major Category

Pesticides

Synonyms

2-Pyridinol, 3,5,6-trichloro-, O-ester with O,O-diethyl; phosphorothioate; Bonidel; Brodan; Chlorpyrifos ethyl; Chlorpyrifos-ethyl; Chlorpyriphos; Chlorpyriphos [ISO-French]; Chlorpyriphos-ethyl; Coroban; Danusban; Detmol U.A.; Detmol ua; Dhanusban; Dowco 179; Durmet; Dursban; Dursban 10CR; Dursban 44; Dursban 4E; Dursban F; Dursban R; Equity; Ethyl chlorpyriphos; Geodinfos; Grofo; Killmaster; Lentrek; Lock-On; Lorsban; Lorsban 50SL; O,O-Diaethyl-O-3,5,6-trichlor-2-pyridylmonothiophosphat [German]; O,O-Diethyl O-(3,5,6-trichloro-2-pyridinyl)phosphorothioate; O,O-Diethyl O-(3,5,6-trichloro-2-pyridyl) phsophorothioate; O,O-Diethyl O-3,5,6-trichloro-2-pyridyl phosphorothioate; OMS-0971; Piridane; Pyrinex; Radar; Radar (fungicide); Spannit; Stipend; Suscon; Tafaban; Terial; Terial 40L; Trichlorpyrphos; XRM 429; XRM 5160; Zidil; suSCon Blue; suSCon Green; [ChemIDplus]

Category

Organophosphate Insecticides

Description

Colorless to white, crystalline solid with a mild, mercaptan-like odor. [pesticide] [NIOSH]

Sources/Uses

Widely used in homes and on farms for cockroaches, fleas, termites, ticks, and crop pests; [ATSDR ToxFAQs]

Comments

The EPA reentry interval is 24 hours for emulsifiable concentrate or wettable powder if workers are not wearing protective clothing. Chlorpyrifos is classified as "moderately toxic." [EXTOXNET] A small number of the organophosphates (OPs) can Induce Delayed Neuropathy (OPIDN). OPIDN usually occurs after ingestion and is usually nonoccupational. [Levy, p. 431] The average of two baseline respective cholinesterase activity determinations three days apart, with no exposures to enzyme inhibiting pesticides for at least 30 days, is recommended for each worker prior to exposure to cholinesterase inhibitors because of large inter-individual differences in published baseline values. To be established at least once a year. Removal from workplace exposures is recommended until the cholinesterase activity returns to within 20% of baseline. [TLVs and BEIs]

Reference Link

EXTOXNET PIP - CHLORPYRIFOS

Exposure Assessment
BEI

Acetylcholinesterase activity in red blood cells = 70% of individual's baseline; Butylcholinesterase activity in serum or plasma = 60% of individual's baseline; Sample at end of shift; [TLVs and BEIs]

Skin Designation (ACGIH)

Yes

TLV (ACGIH)

0.1 mg/m3, inhalable fraction and vapor

Vapor Pressure

2.0E-5 mm Hg

Reference Link

ATSDR - ToxFAQs - Chlorpyrifos

Adverse Effects
Neurotoxin

Motor Neuropathy

Other Poison

Organophosphate

ACGIH Carcinogen

Not Classifiable

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

Search ChemIDplus

Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: