Agent Name

Allyl isothiocyanate

CAS Number

57-06-7

Formula

C4-H5-N-S

Major Category

Nitrogen Compounds

Synonyms

1-Propene, 3-isothiocyanato-; 2-Propenyl isothiocyanate; 3-Isothiocyanato-1-propene; AITC; Allyl isosulfocyanate; Allyl isosulphocyanate; Allyl isothiocyanate; Allyl isothiocyanate (natural); Allyl isothiocyanate, non-perfume grade; Allyl mustard oil; Allyl sevenolum; Allyl thioisocyanate; Allylisothiokyanat [Czech]; Allylsenevol; Allylsenfoel; Allylsenfoel [German]; Allylsevenolum; Allyspol; Allyspol 75EC; Artificial mustard oil; Artificial oil of mustard; Carbospol; Isothiocyanate d'allyle [French]; Isothiocyanic acid allyl ester; Isothiocyansaeureallylester; Mustard oil; Mustard oil (VAN); Mustard oil, volatile; Mustard oil, volatile, synthetic; Oil of mustard; Oil of mustard BPC 1949; Oil of mustard, artificial; Oleum sinapis; Oleum sinapis volatile; Redskin; Senf oel [German]; Senfoel; Synthetic mustard oil; Volatile mustard oil; Volatile oil of mustard; [ChemIDplus] UN1545

Category

Isothiocyanates

Description

Colorless or pale yellow, very refractive liquid; very pungent, irritating odor; [Merck Index]

Sources/Uses

Used to make flavors and war gases; Used medically as a counterirritant; [ChemIDplus] Used as a fungicide, insecticide fumigant, and a repellent for cats and dogs; Also used in some model airplane cements to deter glue sniffers and externally as a rubefacient; [HSDB] "Generally recognized as safe" by the FDA as a food additive; Used as an ethanol denaturant; [AIHA]

Comments

A skin, eye, and respiratory tract irritant; Tear drawing; May cause skin sensitization; May cause liver injury; [ICSC] "The vapor is lacrimogenic and can cause keratitis which interferes with vision." [HSDB] Toxic by skin contact and ingestion; A vesicant--causes burns; Lachrymator; May cause pneumonitis and pumonary edema after inhalation of high concentration; [MSDSonline] Reported occupational adverse effects are cutaneous allergy and severe respiratory tract irritation; Threshold for respiratory irritation is about 4 ppm; [AIHA]

Reference Link

Allergic contact dermatitis from allyl isothiocyanate in a Danish cohort of 259 selected patients.

Exposure Assessment
WEEL

STEL = 1 ppm

Vapor Pressure

4 mm Hg

Odor Threshold Low

0.008 ppm

Odor Threshold High

0.42 ppm

Explanatory Notes

VP = 3.7 mm Hg at 30 deg C; [ChemIDplus] Flash point = 46 deg C; [ICSC] Odor thresholds from AIHA;

Flammability (NFPA)

2: High ambient temperature required

Adverse Effects
Skin Sensitizer

Yes

Lacrimator

Yes

Toxic Pneumonitis

Yes

Hepatotoxin

Hepatotoxin, Secondary

Dermatotoxin

Skin Burns

IARC Carcinogen

Not Classifiable

Links to Other NLM Databases
Health Studies

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Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: