Agent Name

1,2,3,4-Tetrachlorobenzene

CAS Number

634-66-2; 63697-20-1

Formula

C6-H2-Cl4

Major Category

Other Classes

Synonyms

Benzene, 1,2,3,4-tetrachloro-; [ChemIDplus]

Category

Halogenated Monoaromatics

Description

White solid; [Hawley] Colorless crystals; [MSDSonline]

Sources/Uses

Used as a component of dielectric fluids and as a chemical intermediate; [HSDB] Used in commercial trichlorobenzene mixtures for electrical insulating fluids in transformers; A break-down product of the pesticide Lindane; [CHEMINFO]

Comments

A decrease in the number of fetuses was the only significant effect observed at the highest dose level (200 mg/kg) in a study with pregnant rats (no teratogenic effects or histopathological changes in mothers or fetuses); Caused histological changes to liver and kidney in 13 week feeding study with rats; [HSDB] May cause irritation to skin, eyes, nose, throat, and respiratory tract; Long term exposure may cause kidney and liver injury; [CHEMINFO] Effects to the liver in short term gavage studies with rats include porphyria, enlargement, and focal necrosis; Histopathological changes observed to kidney and liver in 90 day feeding study with rats; [INCHEM]

Exposure Assessment
Vapor Pressure

0.03 mm Hg

Explanatory Notes

Flash point > 113 deg C; [CAMEO]

Flammability (NFPA)

1: Must be preheated

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

Links to Other NLM Databases
Health Studies

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Toxicity Information

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Chemical Information

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Processes

Industrial Processes with risk of exposure: