Agent Name

Thiram

Alternative Name

TMTD

CAS Number

137-26-8

Formula

C6-H12-N2-S4

Major Category

Pesticides

Synonyms

Tetramethylthiuram disulfide; Thiuram; TMTD; TMT; TMTDS; Attack; Arasan; Aules; Fermide 850; Fernasan; FMC 2070; Hexathir; Mercuram; Micropearls; Nomersan; Pomarsol; Puralin; Rezifilm; Rhodiasan Express; Spotrete; Tersan; Thiosan; Thiotox; Thiramad; Thirame; Thiuramin; Thirasan; Tirampa; Tiuramyl; TMTC; TMTD 50 Borches; Trametan; Tuads; Tulisan

Category

Dithiocarbamates (Pesticide)

Description

Colorless to yellow, crystalline solid with a characteristic odor. [Note: Commercial pesticide products may be dyed blue; [NIOSH]

Sources/Uses

Used as a crop fungicide and seed protectant; also used as an animal repellent to protect fruit trees and ornamentals; [EXTOXNET] Used as a fungicide applied to foliage; Also used in seed treatment, as a rodent repellent, a vulcanizing agent, and additive to lubricating oil; [ACGIH]

Comments

An irritant and a skin sensitizer, thiram is classified as "slightly toxic." [EXTOXNET] No increased tumors in chronic studies of rodents; "Reproductive endpoints are not generally altered and the fetal animal does not appear to be more sensitive." [ACGIH] The EBCDCs (ethylenebisdithiocarbamates) can cause irritant and allergic contact dermatitis. EBDCs include ferbam, vapam, maneb, mancozeb, zineb, thiram, and ziram. They are also used as rubber accelerators. Ethylene thiourea (ETU), which may contaminate EBCDCs, is carcinogenic and teratogenic in animal experiments. [LaDou, p. 610] ETU is the major metabolite of EBDCs. [Krieger, p. 1690] See the agent, "Ethylene thiourea."

Reference Link

EXTOXNET PIP - THIRAM

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

TLV (ACGIH)

0.05 mg/m3, inhalable fraction and vapor

PEL (OSHA)

5 mg/m3

MAK

1 mg/m3, inhalable fraction

IDLH (NIOSH)

100 mg/m3

Excerpts from Documentation for IDLHs

Basis for revised IDLH: The revised IDLH for thiram is 100 mg/m3 based on acute inhalation toxicity data in animals [Marhold 1986]. This may be a conservative value due to the lack of relevant acute inhalation toxicity data for workers.

Vapor Pressure

8.0E-6 mm Hg

Lethal Concentration

LC50 (rat) = 500 mg/m3/4H

Reference Link

ICSC: Thiram

Adverse Effects
Skin Sensitizer

Yes

IARC Carcinogen

Not Classifiable

ACGIH Carcinogen

Not Classifiable

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: