Agent Name

1,2,3,5-Tetrachlorobenzene

CAS Number

634-90-2; 63697-21-2

Formula

C6-H2-Cl4

Major Category

Other Classes

Synonyms

Benzene, 1,2,3,5-tetrachloro-; [ChemIDplus] 1,2,3,5-Benzene tetrachloride; 1,2,4,6-Tetrachlorobenzene; [CAMEO]

Category

Halogenated Monoaromatics

Description

Colorless solid; [HSDB] White or off-white solid; [CAMEO]

Sources/Uses

Used as an intermediate for herbicides and defoliants; as an insecticide; as an impregnant for moisture resistance; for electrical insulation; for temporary protection in packing; Not commercially produced in the US; [HSDB] Used for electrical insulating fluids in transformers; A break-down product of the pesticide Lindane; [CHEMINFO]

Comments

A decrease in the number of fetuses was the only significant effect observed at the highest dose level (200 mg/kg) in a study with pregnant rats (no teratogenic effects or histopathological changes in mothers or fetuses); Caused histological changes to liver and kidney in 13 week feeding study with rats; Effects in two month feeding study include altered liver function, prothrombin index, blood cholesterol, and adrenal hypertrophy; [HSDB] May cause irritation to skin, eyes, nose, throat, and respiratory tract; Long term exposure may cause kidney and liver injury; [CHEMINFO] Effects to the liver in short term gavage studies with rats include porphyria, enlargement, and focal necrosis; Histopathological changes observed to kidney and liver in 90 day feeding study with rats; [INCHEM]

Exposure Assessment
Vapor Pressure

0.07 mm Hg

Explanatory Notes

Flash point > 113 deg C; [CAMEO]

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

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