Agent Name

1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin

CAS Number

57653-85-7

Formula

C12-H2-Cl6-O2

Major Category

Other Classes

Synonyms

1,2,3,6,7,8-HXCDD; 1,2,3,6,7,8-Hexa polychlorinated dibenzo-p-dioxin; 1,2,3,6,7,8-Hexachlorodibenzo-para-dioxin; 1,2,3,6,7,8-Hexachlorodibenzodioxin; Dibenzo(b,e)(1,4)dioxin, 1,2,3,6,7,8-hexachloro-; Dibenzo-p-dioxin, 1,2,3,6,7,8-hexachloro-; [ChemIDplus]

Category

Halogenated Polyaromatics

Description

White solid; [CAMEO] White crystals; [MSDSonline]

Sources/Uses

Found in emissions from waste incineration and PCB transformer fires and as impurity in chlorinated pesticides and pentachlorophenol; Not commercially produced; [HSDB] Hexachlorodibenzo-p-dioxins (HCDD): Found as impurities in polychlorinated phenols and chlorophenol derivative herbicides (i.e. 2,4-D); [NTP]

Comments

Ingestion, inhalation and skin contact to this class of compounds has caused chloracne and liver injury; [CAMEO] Polychlorodibenzodioxins have caused chloracne in humans; Produced acnegenic response in rabbit ear bioassay; Teratogenic in rats at doses maternally toxic; Hexachlorodibenzo-p-dioxin mixtures have induced carcinomas, adenomas and non-neoplastic lesions in experimental animals by ingestion and external application; Oral LD50 (rat) = 1.8 (male) and 0.8 (female) mg/kg bw (31% 1,2,3,6,7,8- and 67% 1,2,3,7,8,9-hexachlorodibenzo-p-dioxins); [HSDB] No evidence of carcinogenicity in mice with dermal application, but carcinogenic effects, including hepatocellular carcinomas, observed in gavage study with rats and mice (mixture of 1,2,3,6,7,8- and 1,2,3,7,8,9-hexachlorodibenzo-p-dioxins); [NTP] IARC classification is for polychlorinated dibenzo-para-dioxins other than 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD);

Exposure Assessment
Vapor Pressure

3.6E-11 mm Hg

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

Reproductive Toxin

Yes

Dermatotoxin

Chloracne

IARC Carcinogen

Not Classifiable

NTP Carcinogen

Anticipated Human Carcinogen

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: