Agent Name

1,2-Dibromo-3-chloropropane

Alternative Name

DBCP

CAS Number

96-12-8

Formula

C3-H5-Br2-Cl

Major Category

Pesticides

Synonyms

Dibromochloropropane; DBCP; [NIOSH]

Category

Fumigants

Description

Dense yellow or amber liquid with a pungent odor at high concentrations. [pesticide] [Note: A solid below 43 degrees F.] [NIOSH]

Comments

Strong positive data for testicular damage in animals and decreased sperm counts, azoospermia, and hormonal changes in humans; [ATSDR Case Studies # 29] "Germ cell mutagens that have shown to increase the mutant frequency in the progeny of exposed mammals." [MAK]

Restricted

All uses except on pineapple plantations in Hawaii canceled in 1979; use on pineapples cancelled in 1985; See 29CFR1910.1044;

Exposure Assessment
PEL (OSHA)

0.001 ppm

Vapor Pressure

0.8 mm Hg

Lethal Concentration

LC50 (rat) = 103 ppm/8H

Half Life

Animal studies: 80% of absorbed dose eliminated within 24 hours; [TDR, p. 479]

Reference Link

ATSDR - ToxFAQs - 1,2-Dibromo-3-Chloropropane

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

Reproductive Toxin

Yes

IARC Carcinogen

Possible Carcinogen

NTP Carcinogen

Anticipated Human Carcinogen

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: