Agent Name

1,2-Diaminocyclohexane

CAS Number

694-83-7

Formula

C6-H14-N2

Major Category

Nitrogen Compounds

Synonyms

1,2-Cylohexanediamine; Cyclohex-1,2-ylenediamine; [ChemIDplus] UN2735

Category

Amines, Aromatic

Description

Dark liquid with an amine odor; [CAMEO]

Sources/Uses

Used to make bicyclic pyrazine derivatives; [HSDB]

Comments

A corrosive substance; [CAMEO] Effects during recovery period from a 4-hour, lethal-concentration study of rats include skin lesions, discharge from the nose, and labored breathing; Lesions of the nasal mucosa observed in 2-week inhalation study with rats; No other gross or histopathological changes observed; Considered a severe skin and moderate eye irritant based on studies with rabbits; Not sensitizing to skin of guinea pigs; Dermal LD50 (test substance 69.5% 1,6-Hexanediamine and 30.5% 1,2-Diaminocyclohexane) = 7500 mg/kg in albino rabbits and produced severe irritation with necrosis; [EPA HPVIS] Observations in 28-day feeding with rats at highest tested dose (500 mg/kg) include pale discoloration of liver and increased liver enzymes; Decrease in litter size and increased postnatal loss at highest dose; Caused skin sensitization in guinea pigs (20/20 at 24 hours and 13/20 at 48 hours) [ToxPlanet: TSCATS] Causes burns; Potential skin sensitizer; May cause acute pneumonitis after inhalation; [Alfa Aesar MSDS]

Reference Link

Review of the toxicology of three alkyl diamines.

Exposure Assessment
Vapor Pressure

0.4 mm Hg

Lethal Concentration

LCLo (rat) = 3,200 mg/m3/4h

Explanatory Notes

Flash point > 93 deg C; [CAMEO] The Guide in the Emergency Response Guidebook is for "Amines, liquid, corrosive, n.o.s."

Adverse Effects
Skin Sensitizer

Yes

Toxic Pneumonitis

Yes

Hepatotoxin

Hepatotoxin, Secondary

Dermatotoxin

Skin Burns

Links to Other NLM Databases
Health Studies

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Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: