Agent Name

1,2-Dihydro-2,2,4-trimethylquinoline

CAS Number

147-47-7

Formula

C12-H15-N

Major Category

Nitrogen Compounds

Synonyms

2,2,4-Trimethyl-1,2-dihydrochinolin [Czech]; 2,2,4-Trimethyl-1,2-dihydroquinoline; Acetone anil; Acetone anil (quinoline deriv.); Acetone anil (quinoline derivative); Agerite resin D; Flectol A; Flectol H; Flectol pastilles; Polnox R; Quinoline, 1,2-dihydro-2,2,4-trimethyl-; Trimethyl dihydroquinoline; Trimethyl-1,2-dihydroquinoline; Vulkanox HS/LG; Vulkanox HS/powder; [ChemIDplus]

Category

Quinolines

Description

Light tan powder; mp = 120 deg C; [HSDB] Dark cloudy copper-colored or yellow liquid; mp = 26-27 deg C; [CAMEO] Amber or brown granules; mp = 80-100 deg C; [Redox MSDS]

Sources/Uses

Used as a monomer; The polymer is a rubber antioxidant; [HSDB]

Comments

Weight loss, decreased hemoglobin, CNS depression, and abnormal liver function observed in rats dosed long-term by intragastric tube; [HSDB] No evidence of carcinogenicity in mice or female rats and some evidence of carcinogenicity in male rats in 2-year dermal studies; [NTP] Causes thymus and liver changes and weight loss in 13-week intermittent dermal study of rats; Causes changes in urine and serum composition and weight loss in 21-week intermittent inhalation study of rats; Causes impaired liver function in 30-day intermittent oral study of rats; [RTECS] May cause skin sensitization, eye irritation, and respiratory tract irritation; [Redox MSDS] Search for 147-47-7 AND (sensitizer OR sensitization OR allergic): no results; [PubMed]

Exposure Assessment
Explanatory Notes

Flash point = 101 deg C; [CAMEO]

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Other Information

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