Agent Name

1,3-Diamino-2-thiourea

Alternative Name

Thiocarbazide

CAS Number

2231-57-4

Formula

C-H6-N4-S

Major Category

Nitrogen Compounds

Synonyms

Thiocarbazide; Thiocarbohydrazide; Carbohydrazide, thio-; Carbonothioic dihydrazide; Hydrazinecarbohydrazonothioic acid; Hydrazinecarbohydrazonothioic acid (VAN); TCH; Thiocarbazide; Thiocarbonic dihydrazide; Thiocarbonohydrazide; [ChemIDplus]

Category

Thiourea Compounds

Description

Solid; [CAMEO] White powder; [Alfa Aesar MSDS]

Sources/Uses

Used in electron microscopy to deposit electron-opaque material for ultrastructural analysis and as a veterinary medication; [HSDB] Used to make pesticides and other agricultural chemicals; [EPA]

Comments

Emergency treatment: "Thiocarbazide"; Causes seizures in animal experiments; No reports of human poisoning cases; [HSDB] Not irritating to rabbit skin or eyes; Muscle spasms observed in lethal-dose studies of rats (oral and inhalation); Causes gene mutations in bacteria and unscheduled DNA synthesis in vitro; [EPA ChAMP] A mild eye irritant; Causes convulsions, somnolence, and dyspnea in oral lethal-dose studies of rats, guinea pigs, and mice; [RTECS] An irritant; [Alfa Aesar MSDS]

Exposure Assessment
Lethal Concentration

LC50 (rat) = 50 mg/m3/4h

Adverse Effects
Neurotoxin

Other CNS Neurotoxin

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Other Information

No other related information on this agent was found.