Agent Name

Talc (containing no asbestos)

CAS Number

14807-96-6

Formula

H2-O3-Si. 3/4Mg

Major Category

Mineral Dusts

Synonyms

Hydrous magnesium silicate; Steatite talc; [NIOSH]

Category

Other Mineral Dusts

Description

Odorless, white powder; Containing no asbestos and less than 1% quartz; [NIOSH]

Sources/Uses

Used as a paint additive and rubber lubricant; [Levy, p. 422] Crystalline silica not bound to other minerals is "free" silica. Silicates are minerals in which silicon and oxygen are combined with other elements. [Rom, p. 364]

Comments

Interstitial fibrosis can develop in workers heavily exposed to talc, but it is not yet clear how much is due to talc versus talc contaminants. [Harber, p. 349]

Reference Link

Effects of talc dust on respiratory health: result...[Occup Environ Med. 2008] - PubMed Result

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

TLV (ACGIH)

2 mg/m3, respirable fraction (particulate matter containing no asbestos and < 1% crystalline silica)

PEL (OSHA)

20 mppcf, containing < 1% quartz

IDLH (NIOSH)

1000 mg/m3

Excerpts from Documentation for IDLHs

Basis for revised IDLH: The available toxicological data contain no evidence that an acute exposure to a high concentration of talc would impede escape or cause any irreversible health effects within 30 minutes. However, the revised IDLH for talc is 1,000 mg/m3 based on being 500 times the NIOSH REL of 2 mg/m3 (500 is an assigned protection factor for respirators and was used arbitrarily during the Standards Completion Program for deciding when the "most protective" respirators should be used for particulates).

Reference Link

IARC 2010: Talc (not containing asbestos)

Adverse Effects
Fibrogenic

Yes

IARC Carcinogen

Not Classifiable

ACGIH Carcinogen

Not Classifiable

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure:

Activities

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