Agent Name

Ethyleneimine

Alternative Name

Ethylenimine

CAS Number

151-56-4

Formula

C2-H5-N

Major Category

Toxic Gases & Vapors

Synonyms

Ethylenimine; 1H-Azirine, dihydro-; Aethylenimin [German]; Azacyclopropane; Aziran; Aziridin [German]; Aziridine; Dihydro-1H-azirine; Dihydroazirene; Dihydroazirine; Dimethyleneimine; Ethyleenimine [Dutch]; Ethyleneimine; Etilenimina [Italian]; TL 337; [ChemIDplus] UN1185

Category

Other Toxic Gases & Vapors

Description

Colorless liquid with an ammonia-like odor; Note: Usually contains inhibitors to prevent polymerization; [NIOSH]

Sources/Uses

Used to produce polyethyleneimine and other organic chemicals; [ACGIH] Used in the paper, textile, petroleum, lacquer, cosmetic, and photography industries; [HSDB]

Comments

Liquid causes first degree burns on short exposure and second degree burns on long exposure; [CHRIS] Skin sensitization, mucous membrane irritation, liver and kidney injury, and toxic pneumonitis have been seen after occupational exposure; [ACGIH] A lachrymator; [HSDB] "Germ cell mutagens that have shown to increase the mutant frequency in the progeny of exposed mammals." [MAK]

Restricted

Regulated as a carcinogen--See 29CFR1910.1003 (Code of Federal Regulations pertaining to the manufacturing, processing, repackaging, releasing, handling, and storing of this chemical);

Exposure Assessment
Skin Designation (ACGIH)

Yes

TIH

Yes

TLV (ACGIH)

0.05 ppm

STEL (ACGIH)

0.1 ppm

IDLH (NIOSH)

100 ppm

Excerpts from Documentation for IDLHs

Other animal data: It has been reported that rats and guinea pigs survived 2hour exposures to 50 ppm [Carpenter et al. 1949]. . . .Human data: Exposure to concentrations greater than 100 ppm has caused respiratory tract irritation and inflammation, but symptoms may be delayed several hours [Gosselin et al. 1976]. Also, it has been presumed that severe exposures might result in an overwhelming pulmonary edema since ethyleneimine is a powerful lacrimator and emetic [Gosselin et al. 1976].

Vapor Pressure

213 mm Hg

Odor Threshold Low

2 ppm

Lethal Concentration

LC50 (rat) = 100 mg/m3/2H

Explanatory Notes

Odor threshold from CHEMINFO; The Guide from the Emergency Response Guidebook is for "ethylenimine, inhibited." Flash point = -11 deg C;

Half Life

No reports found; [TDR, p. 688]

Reference Link

ICSC: Ethyleneimine

Flammability (NFPA)

3: May ignite at ambient temperature

Adverse Effects
Skin Sensitizer

Yes

Lacrimator

Yes

Toxic Pneumonitis

Yes

Hepatotoxin

Hepatotoxin, Secondary

Nephrotoxin

Yes

Dermatotoxin

Skin Burns

IARC Carcinogen

Possible Carcinogen

ACGIH Carcinogen

Confirmed Animal

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Biomedical References

Search PubMed

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: