Agent Name

beta-Propiolactone

CAS Number

57-57-8

Formula

C3-H4-O2

Major Category

Other Classes

Synonyms

1,3-Propiolactone; 2-Oxetanone; 3-Hydroxypropionic acid lactone; 3-Propanolide; 3-Propiolactone; BPL; Betaprone; Hydracrylic acid beta-lactone; Propanoic acid, 3-hydroxy-, beta-lactone; Propanolide; Propiolactona [INN-Spanish]; Propiolactonum [INN-Latin]; Propiolattone [DCIT]; Propionic acid, 3-hydroxy-, beta-lactone; beta-Propanoic acid lactone; beta-Propiolactone; beta-Propiolakton [Czech]; beta-Propionolactone; beta-Proprolactone; [ChemIDplus] UN2810

Category

Lactones

Description

Colorless liquid with a slightly sweet odor; [NIOSH]

Sources/Uses

Used as a sterilant in medicine for biological pharmaceuticals and surgical instruments; also used as a disinfectant and chemical intermediate; [ACGIH]

Comments

Causes permanent corneal opacification when tested in the rabbit eye and scarring when tested on mouse skin; Avoid contact because of its carcinogenic potential; [ACGIH] Causes second degree burns after a few minutes of skin exposure; [CHRIS] Corrosive to the eyes; [ICSC] Irritating to the skin and eyes; Very toxic by inhalation; Inhalation of high concentration may cause chemical pneumonitis; [MSDSonline] Causes liver injury in high-dose animal studies; [HSDB]

Restricted

Regulated as a carcinogen: See 29CFR1910.1013 (Code of Federal Regulations pertaining to the manufacturing, processing, repackaging, releasing, handling, and storing of this chemical).

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

TLV (ACGIH)

0.5 ppm

Vapor Pressure

3 mm Hg

Lethal Concentration

LC50 (rat) = 25 ppm/6h

Explanatory Notes

Flash point = 74 deg C;

Half Life

No reports found; [TDR, p. 1048]

Flammability (NFPA)

2: High ambient temperature required

Adverse Effects
Toxic Pneumonitis

Yes

Hepatotoxin

Hepatotoxin, Secondary

Dermatotoxin

Skin Burns

IARC Carcinogen

Possible Carcinogen

NTP Carcinogen

Anticipated Human Carcinogen

ACGIH Carcinogen

Confirmed Animal

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Related Information in HazMap
Processes

Industrial Processes with risk of exposure: