Agent Name | 1,4-Butanediol |
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CAS Number | 110-63-4 |
Formula | C4-H10-O2 |
Major Category | Other Classes |
Synonyms | 1,4-BD; 1,4-Butylene glycol; 1,4-Dihydroxybutane; 1,4-Tetramethylene glycol; Agrisynth B1D; Butane-1,4-diol; Butanediol; DIOL 14B; Sucol B; Tetramethylene 1,4-diol; Tetramethylene glycol; [ChemIDplus] |
Category | Alcohols and Polyols, Other |
Description | Colorless liquid; [Hawley] Hygroscopic; [CAMEO] Colorless liquid or yellow melt; mp 19-20 deg C; [MSDSonline] |
Sources/Uses | Used as a chemical intermediate for tetrahydrofuran and other acetylenic chemicals; as a monomer for polybutylene terephthalate resins; as a chain extender for polyurethane resins; as an intermediate in polyester resins; in the production of 1,4-butanediol dimethanesulfonate (myleran); Also used as a humectant; [HSDB] Used as a solvent, an intermediate for plasticizers, and a cross-linking agent in polyurethane elastomers; [Hawley] |
Comments | Emergency treatment: "Glycols"; [HSDB] Pregnant female mice had sedation at 300-600 mg/kg/day by gavage; Increased fetal skeletal defects at 600 mg/kg/day; [NTP] A CNS depressant; [ICSC] A mild skin, eye, and respiratory tract irritant; Metabolized to gamma- hydroxybutyric acid, a CNS depressant; [Reference #1] Causes somnolence and change in righting reflex in lethal-dose feeding studies of rats; [MSDSonline] |
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Exposure Assessment | |
Vapor Pressure | 0.01 mm Hg |
Lethal Concentration | LCLo (rat) = 15,000 mg/m3/4h |
Explanatory Notes | Flash point = 121 deg C; [ICSC] |
Flammability (NFPA) | |
Adverse Effects | |
Neurotoxin | CNS Solvent Syndrome |
Links to Other NLM Databases | |
Health Studies | Human Health Effects from Hazardous Substances Data Bank: |
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Chemical Information | |
Related Information in HazMap | |
Diseases | Occupational diseases associated with exposure to this agent: |
Processes | Industrial Processes with risk of exposure: |