Agent Name

1,4-Butanediol

CAS Number

110-63-4

Formula

C4-H10-O2

Major Category

Other Classes

Synonyms

1,4-BD; 1,4-Butylene glycol; 1,4-Dihydroxybutane; 1,4-Tetramethylene glycol; Agrisynth B1D; Butane-1,4-diol; Butanediol; DIOL 14B; Sucol B; Tetramethylene 1,4-diol; Tetramethylene glycol; [ChemIDplus]

Category

Alcohols and Polyols, Other

Description

Colorless liquid; [Hawley] Hygroscopic; [CAMEO] Colorless liquid or yellow melt; mp 19-20 deg C; [MSDSonline]

Sources/Uses

Used as a chemical intermediate for tetrahydrofuran and other acetylenic chemicals; as a monomer for polybutylene terephthalate resins; as a chain extender for polyurethane resins; as an intermediate in polyester resins; in the production of 1,4-butanediol dimethanesulfonate (myleran); Also used as a humectant; [HSDB] Used as a solvent, an intermediate for plasticizers, and a cross-linking agent in polyurethane elastomers; [Hawley]

Comments

Emergency treatment: "Glycols"; [HSDB] Pregnant female mice had sedation at 300-600 mg/kg/day by gavage; Increased fetal skeletal defects at 600 mg/kg/day; [NTP] A CNS depressant; [ICSC] A mild skin, eye, and respiratory tract irritant; Metabolized to gamma- hydroxybutyric acid, a CNS depressant; [Reference #1] Causes somnolence and change in righting reflex in lethal-dose feeding studies of rats; [MSDSonline]

Reference Link

OECD SIDS: 1,4-Butanediol - 2000

Exposure Assessment
Vapor Pressure

0.01 mm Hg

Lethal Concentration

LCLo (rat) = 15,000 mg/m3/4h

Explanatory Notes

Flash point = 121 deg C; [ICSC]

Adverse Effects
Neurotoxin

CNS Solvent Syndrome

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: