Agent Name

1,4-Epoxy-p-menthane

CAS Number

470-67-7

Formula

C10-H18-O

Major Category

Other Classes

Synonyms

1,4-Cineol; 1,4-Cineole; 1,4-Cineole (natural); 1-Isopropyl-4-methyl-7-oxabicyclo(2.2.1)heptane; 1-Methyl-4-(1-methylethyl)-7-oxabicyclo(2.2.1)heptane; 7-Oxabicyclo(2.2.1)heptane, 1-isopropyl-4-methyl- (6CI); 7-Oxabicyclo(2.2.1)heptane, 1-methyl-4-(1-methylethyl)-; Isocineole; p-Cineole; p-Menthane, 1,4-epoxy-; [ChemIDplus] UN1993

Category

Other Organic Compounds

Description

Colorless liquid with a minty lime odor; [HSDB]

Sources/Uses

Used as a flavoring and fragrance agent; Naturally occurring in some essential oils; [HSDB]

Comments

Safe when used as a flavoring agent in food; [JECFA] 1,8-Cineole (eucalyptol) is toxic by ingestion; As little as 1 mL can cause coma and 3.5 mL can cause death; Patients may have epigastric burning, nausea, ataxia, muscle weakness, delirium, stupor, and occasionally convulsions; Recovery reported after a dose as high as 30 mL; In a series of 109 children, eucalyptus oil ingestion caused only minor CNS depression when dose was 2-3 mL; [HSDB] May cause irritation; [MSDSonline]

Exposure Assessment
Vapor Pressure

1.93 mm Hg

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Flammable liquid, n.o.s."

Adverse Effects
Neurotoxin

CNS Solvent Syndrome

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: