Agent Name

N-Nitrosodimethylamine

Alternative Name

N,N-Dimethylnitrosoamine

CAS Number

62-75-9

Formula

C2-H6-N2-O

Major Category

Nitrogen Compounds

Synonyms

N,N-Dimethylnitrosoamine; DMN; DMNA; Dimethylamine, N-nitroso-; Dimethylnitrosamin [German]; Dimethylnitrosamine; Dimethylnitrosoamine; Methanamine, N-methyl-N-nitroso-; N,N-Dimethylnitrosamine; N-Dimethyl-nitrosamine; N-Methyl-N-nitrosomethanamine; N-Nitroaodimethylamine; N-Nitroso-N,N-dimethylamine; N-Nitrosodimethylamine; NDMA; Nitrosamine, dimethyl-; Nitrosodimethylamine; [ChemIDplus] UN2810

Category

Nitrosamines

Description

Yellow, oily liquid with a faint, characteristic odor; [NIOSH]

Sources/Uses

Used as an intermediate in the production of 1,1-dimethylhydrazine; DMNA contaminates common organic amines and may occur as a byproduct of industrial processes; [ACGIH]

Comments

A animal carcinogen; At least one death and a number of cases of hepatic injury have been reported in workers handling DMNA. [ACGIH] A skin, eye, and respiratory tract irritant; May cause liver injury and jaundice; [ICSC]

Restricted

Regulated as a carcinogen: See 29CFR1910.1003 (Code of Federal Regulation).

Exposure Assessment
Skin Designation (ACGIH)

Yes

Vapor Pressure

3 mm Hg

Odor Threshold Low

0.0079 ppm

Odor Threshold High

0.01 ppm

Lethal Concentration

LC50 (rat) = 78 ppm/4h

Explanatory Notes

Carcinogen--No TLV; Odor threshold from AIHA; Flash point = 142 deg F;

Half Life

No reports found; [TDR, p. 955]

Reference Link

ATSDR - ToxFAQs - n-Nitrosodimethylamine

Adverse Effects
Hepatotoxin

Hepatotoxin, Primary

IARC Carcinogen

Probable Carcinogen

NTP Carcinogen

Anticipated Human Carcinogen

ACGIH Carcinogen

Confirmed Animal

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: