Agent Name

1'-Hydroxysafrole

CAS Number

5208-87-7

Formula

C10-H10-O3

Major Category

Other Classes

Synonyms

1,2-Methylenedioxy-4-(1-hydroxyallyl)benzene; 1,3-Benzodioxole-5-(2-propen-1-ol); 1,3-Benzodioxole-5-methanol, alpha-ethenyl-; Piperonyl alcohol, alpha-vinyl-; alpha-Ethenyl-1,3-benzodioxole-5-methanol; [ChemIDplus]

Category

Other Aromatic Compounds

Comments

A mutagen and tumorigen; [RTECS] Emergency treatment: "Sassafras oil"; Safrole is the toxic agent in sassafras oil; Safrole is classified as 2B (possible human carcinogen) by IARC; Safrole is metabolized in the body to 1'-hydroxysafrole; Ingestion of 5 ml of sassafras oil can cause severe symptoms (tachycardia, hypotension, and respiratory paralysis) or death; Large doses may damage the liver; Drinking 10 cups of sassafras tea caused sweating in one adult subject; [HSDB] See "Safrole."

Exposure Assessment
Vapor Pressure

7.78E-5 mm Hg

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

Links to Other NLM Databases
Health Studies

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Toxicity Information

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Other Information

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