Agent Name

Allyl chloride

CAS Number

107-05-1

Formula

C3-H5-Cl

Major Category

Solvents

Synonyms

3-Chloropropene; 1-Chloro-2-propene; 3-Chloro-1-propene; 3-Chloropropylene; Chloroallylene; [NIOSH]

Category

Chlorinated Aliphatics

Description

Colorless, brown, yellow, or purple liquid with a pungent, unpleasant odor; [NIOSH] Odor is similar to garlic; [ACGIH]

Sources/Uses

Used in the manufacture of organic chemicals; [ACGIH] Used to make glycerin and epoxy resin; [Rosenstock, p. 676]

Comments

Liquid causes first degree burns on short exposure; [CHRIS] Corrosive to skin; [Quick CPC] Probably a mild eye irritant based on animal studies; [CHEMINFO] Experimental animals suffer no apparent adverse effects after being exposed to 3 ppm, 7 hours/day, 5 days/week for 6 months. Causes liver and kidney damage in subcutaneous lethal dose studies; In acute inhalation exposure studies at concentrations varying from 200 to 2000 ppm, dose dependent kidney damage is observed in rat and mice; Kidney and peripheral nerve injury is observed in mice given 300-500 mg/kg orally 3 times a week for 2-17 weeks. Human volunteers reported odor but no irritation after exposure to 3 ppm for 1-3 minutes; No elevations of kidney or liver function tests were found in a study of 73 males producing chlorinated hydrocarbons and exposed to allyl chloride for an average of 8.2 years; Peripheral neuropathy was reported in 53% of factory workers chronically exposed to allyl chloride. [ACGIH] "Cessation of exposure usually results in good recovery." [Rosenstock, p. 676] Pulmonary edema may result from inhalation of high concentrations. [NJ-HSFS]

Exposure Assessment
Skin Designation (ACGIH)

Yes

TLV (ACGIH)

1 ppm

STEL (ACGIH)

2 ppm

PEL (OSHA)

1 ppm

IDLH (NIOSH)

250 ppm

Excerpts from Documentation for IDLHs

Basis for original (SCP) IDLH. . The chosen IDLH is based on the statement by Deichmann and Gerarde [1969] that a 1-hour exposure to 300 ppm might cause serious effects.

Vapor Pressure

295 mm Hg

Odor Threshold Low

0.48 ppm

Odor Threshold High

5.9 ppm

RD50

2330 ppm

Lethal Concentration

LC50 (rat) = 2000 ppm/4H

Explanatory Notes

Odor threshold from AIHA; Flash point equals -25 deg F; [CHEMINFO]

Half Life

No reports found; [TDR, p. 67]

Reference Link

ICSC: Allyl chloride

Flammability (NFPA)

3: May ignite at ambient temperature

Adverse Effects
Toxic Pneumonitis

Yes

Neurotoxin

Sensorimotor Neuropathy

Hepatotoxin

Hepatotoxin, Secondary

Nephrotoxin

Yes

Dermatotoxin

Skin Burns

IARC Carcinogen

Not Classifiable

ACGIH Carcinogen

Confirmed Animal

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: