Agent Name

1-Chloro-2,6-dinitrobenzene

CAS Number

606-21-3

Formula

C6-H3-Cl-N2-O4

Major Category

Nitrogen Compounds

Synonyms

1,3-Dinitro-2-chlorobenzene; 2,6-Dinitrochlorobenzene; 2-Chloro-1,3-dintrobenzene; Benzene, 2-chloro-1,3-dinitro-; [ChemIDplus] UN1577

Category

Nitros, Aromatic

Description

Yellow solid; [Merck Index] Yellow crystals; [MSDSonline]

Sources/Uses

Used as an intermediate in the manufacture of picric acid; Has been used as a topical adjuvant in immunotherapy of tumors; [HSDB]

Comments

Emergency treatment: "Nitrobenzene." [HSDB] May cause primary and allergic dermatitis; A skin irritant; [Merck Index] Dinitrochlorobenzene (DNCB) is a potent contact allergen that has been used in the treatment of alopecia areata and cutaneous metastasis of malignant melanoma; [Kanerva, p. 1787] An irritant; [MSDSonline]

Adverse Effects
Skin Sensitizer

Yes

Hepatotoxin

Hepatotoxin, Secondary

Methemoglobinemia

Methemoglobinemia, Secondary

Links to Other NLM Databases
Health Studies

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Toxicity Information

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Chemical Information

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Diseases

Occupational diseases associated with exposure to this agent: