Agent Name

1-Chloro-2-methyl-1-propene

CAS Number

513-37-1

Formula

C4-H7-Cl

Major Category

Other Classes

Synonyms

1-Chloro-2-methylpropene; 1-Chloro-2-methylpropene (IUPAC); 1-Chloroisobutylene; 1-Propene, 1-chloro-2-methyl-; 2,2-Dimethylvinyl chloride; 2-Methyl-1-chloropropene; 2-Methyl-1-propenyl chloride; Dimethylvinylchloride; Isocrotyl chloride; Propene, 1-chloro-2-methyl-; alpha-Chloroisobutylene; beta, beta-Dimethylvinyl chloride; beta,beta-Dimethylvinyl chloride; [ChemIDplus] UN1993

Category

Halogenated Aliphatics, Unsaturated

Description

Colorless, highly volatile liquid; [HSDB] Dark yellow to pale orange liquid; [CAMEO] Very faintly yellow-brown liquid; [MSDSonline]

Sources/Uses

Used in organic synthesis and as a research chemical; [Merck Index] Not commercially produced in the US; [HSDB] Impurity in the manufacture of 3-chloro-2-methylpropene; No known commercial use; [IARC]

Comments

An eye and respiratory tract irritant; Possesses anesthetic characteristics; Squamous cell carcinomas have been observed in feeding studies with rats; No evidence of mutagenicity in various strains of Salmonella typhimurium; Emergency medical treatment: see "Propylene dichloride." [HSDB] A skin, eye, and respiratory tract irritant; May cause liver and kidney injury and CNS effects (anesthesia); [CAMEO] Rapidly excreted by expiration and in urine; Effects in high-dose studies with rats include tissue necrosis in various organs (including small and large intestine, thymus, and spleen) and proliferation of forestomach cells; Observations of mutagenicity in single studies with cultured rodent cells (gene mutation and sister chromatid exchange, but no chromosomal aberrations) and insects (gene and chromosomal mutation); Mutagenic to bacteria; Sufficient evidence for carcinogenicity in laboratory animals; [IARC]

Exposure Assessment
Vapor Pressure

212 mm Hg

Lethal Concentration

LC50 (rat) = 400 mg/m3/4h

Explanatory Notes

Flash point = -1 deg C; [CAMEO] The Guide in the Emergency Response Guidebook is for "Flammable liquid, n.o.s."

Adverse Effects
Neurotoxin

CNS Solvent Syndrome

Hepatotoxin

Hepatotoxin, Secondary

IARC Carcinogen

Possible Carcinogen

NTP Carcinogen

Anticipated Human Carcinogen

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: