Agent Name

Amitrole

Alternative Name

3-Amino-1,2,4-triazole

CAS Number

61-82-5

Formula

C2-H4-N4

Major Category

Pesticides

Synonyms

Aminotriazole; 3-Aminotriazole; 2-Amino-1,3,4-triazole; 3-Amino-1,2,4-triazole; Amerol; Amitrol; Amizine; Amizol; Azolan; Azole; Cytrol; Diurol; Weedazol [EXTOXNET]

Category

Herbicides, Other

Description

Colorless to white, crystalline powder. [herbicide] [Note: Odorless when pure.]

Sources/Uses

Used control grasses, broadleafs, poison ivy, and aquatic weeds. [EXTOXNET]

Comments

In the triazole class of herbicides, the known toxicity of amitrole is limited to slight irritant effects. [EPA Pesticides, p. 121] Classified as "slightly toxic," it may be used only by certified applicators. [EXTOXNET] A weed control worker with allergic contact dermatitis was reported; [Kanerva, p. 783] Aminotriazole "may be hepatotoxic on ingestion." [Zimmerman, p. 393] The following herbicides have an oral LD50 of >1 gm/kg and have little or no acute toxicity in humans: Alachlor, Amitrole, Ammonium sulfamate, Atrazine, Dalapon, Dicamba, Glyphosphate, Monuron, Oryzalin, Picloram, Propanil, Simazine, etc. [LaDou, p. 613] TLV basis: thyroid effects; [ACGIH]

Restricted

Use on food crops was canceled by the EPA in 1971; [EXTOXNET]

Reference Link

EXTOXNET PIP - AMITROLE

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

TLV (ACGIH)

0.2 mg/m3

MAK

0.2 mg/m3, inhalable fraction

Vapor Pressure

8.0E-6 mm Hg

Lethal Concentration

LC50 >500 mg/m3

Reference Link

EPA Pesticide Chemical Search

Adverse Effects
Skin Sensitizer

Yes

Hepatotoxin

Hepatotoxin, Secondary

Reproductive Toxin

Yes

IARC Carcinogen

Not Classifiable

NTP Carcinogen

Anticipated Human Carcinogen

ACGIH Carcinogen

Confirmed Animal

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: