Agent Name

sec-Amyl acetate

Alternative Name

2-Pentyl acetate

CAS Number

626-38-0

Formula

C7-H14-O2

Major Category

Solvents

Synonyms

1-Methylbutyl acetate; 2-Acetoxypentane; 2-Amylester kyseliny octove [Czech]; 2-Pentanol, acetate; 2-Pentyl acetate; sec-Amyl acetate; sek.Amylester kyseliny octove [Czech]; [ChemIDplus]

Category

Esters (<C12)

Description

Colorless liquid with a mild odor; [NIOSH]

Sources/Uses

Used as a solvent for ethyl cellulose, nitrocellulose, printing inks; also used in the production of coatings and cements; [ACGIH]

Comments

Esters may induce narcosis in animals, but workers' exposures are limited by irritating effects. See appendix in: [Dick RB, et al. Chemicals in the workplace: incorporating human neurobehavioral testing into the regulatory process. Am J Ind Med. 1998 May;33(5):439-53.] The pentyl acetates are sensory irritants in the work environment. At higher levels in animal experiments, they cause narcosis, hepatotoxicity, and developmental toxicity. [ACGIH]

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

TLV (ACGIH)

50 ppm

STEL (ACGIH)

100 ppm

PEL (OSHA)

125 ppm

MAK

50 ppm

IDLH (NIOSH)

1000 ppm

Excerpts from Documentation for IDLHs

The chosen IDLH is based on the statement by Browning [1965] that exposure to 4,000 ppm of a mixture of n-amyl acetate and isoamyl acetate produced complete loss of reflexes in rabbits within an hour [Koelsch 1912], and on the statement by Sax [1975] that 5,000 ppm n-amyl acetate produced deep narcosis in cats in 30 minutes.

Vapor Pressure

9.78 mm Hg

Odor Threshold Low

0.002 ppm

Odor Threshold High

0.08 ppm

Explanatory Notes

Odor threshold from CHEMINFO; Flash point = 32 deg C;

Half Life

No reports found; [TDR, p. 95]

Flammability (NFPA)

3: May ignite at ambient temperature

Adverse Effects
Neurotoxin

CNS Solvent Syndrome

Hepatotoxin

Hepatotoxin, Secondary

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: