Agent Name

Aniline

CAS Number

62-53-3

Formula

C6-H7-N

Major Category

Nitrogen Compounds

Synonyms

Aminobenzene; Aminophen; Anilin [Czech]; Anilina [Italian, Polish]; Aniline; Aniline oil; Anyvim; Arylamine; Benzenamine; Benzene, amino; Benzidam; Blue Oil; C.I. 76000; C.I. Oxidation Base 1; CI 76000; CI Oxidation Base 1; Cyanol; Huile d'aniline [French]; Krystallin; Kyanol; Phenylamine; [ChemIDplus] UN1547

Category

Amines, Aromatic

Description

Colorless to brown, oily liquid with an aromatic amine-like odor; Note: A solid below 21 degrees F; [NIOSH]

Sources/Uses

Used in the synthesis of dyes, rubber additives, drugs, photographic chemicals, isocyanates, and pesticides. [ACGIH] Shake-out operators and other foundry workers were exposed to aniline from the decomposition of heated cold-box binders. [Appl Occup Environ Hyg 2001 Jan;16(1):66-77]

Comments

Skin contamination is the most common route of occupational exposure. Proper plant design and strict industrial hygiene are necessary to prevent spills and clothing contamination. [ILO Encyclo, Aromatic Amino Compounds] Listed in a table of "Industrial Chemicals for Which Methemoglobin Formation is the Principal Cause of Toxicity"; [ACGIH] A severe eye irritant; Mild symptoms of methemoglobinemia have been reported after several hours exposure to 7-53 ppm. [CHEMINFO]

Reference Link

ATSDR - Medical Management - Aniline

Exposure Assessment
BEI

Total p-aminophenol in urine = 50 mg/L; sample at end of shift; (See notations in ACGIH TLVs and BEIs.)

Skin Designation (ACGIH)

Yes

TLV (ACGIH)

2 ppm

PEL (OSHA)

5 ppm

MAK

2 ppm

IDLH (NIOSH)

100 ppm

Excerpts from Documentation for IDLHs

Human data: Volunteers tolerated 1-hour exposures ranging from 100-160 ppm with only moderate adverse health effects (undefined) [von Oettingen 1941]. It has also been reported that 100 to 160 ppm is the maximum concentration that can be inhaled for 1 hour without serious consequence [Henderson and Haggard 1943] and that 50 to 100 ppm can probably be tolerated for 60 minutes [AIHA 1955].

Vapor Pressure

0.6 mm Hg

Odor Threshold Low

0.58 ppm

Odor Threshold High

10 ppm

Lethal Concentration

LCLo (rat) = 250 ppm/4H

Explanatory Notes

Detection odor threshold from AIHA (mean = 2.4 ppm); Flash point = 70 deg C;

Half Life

Whole body: 4 hours; [TDR, p. 100]

Flammability (NFPA)

2: High ambient temperature required

Adverse Effects
Methemoglobinemia

Methemoglobinemia, Primary

IARC Carcinogen

Not Classifiable

ACGIH Carcinogen

Confirmed Animal

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Biomedical References

Search PubMed

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure:

Activities

Activities with risk of exposure: