Agent Name

o-Anisidine

CAS Number

90-04-0

Formula

C7-H9-N-O

Major Category

Nitrogen Compounds

Synonyms

1-Amino-2-methoxybenzene; 2-Aminoanisole; 2-Anisidine; 2-Methoxy-1-aminobenzene; 2-Methoxyaniline; 2-Methoxybenzenamine; Benzenamine, 2-methoxy-; o-Aminoanisole; o-Anisylamine; o-Methoxyaniline; o-Methoxyphenylamine; ortho-Aminoanisole; ortho-Methoxyaniline; ortho-Methoxyphenylamine; [ChemIDplus] UN2431

Category

Amines, Aromatic

Description

Red or yellow, oily liquid with an amine-like odor; Note: A solid below 41 degrees F; [NIOSH]

Sources/Uses

Used in the synthesis of azo dyes and guaiacol; [ACGIH]

Comments

Hematologic changes, anemia, nephrotoxicity, and bladder cancer occur in animal studies. Workers exposed at 0.4 ppm for 3.5 hours/day for six months did not develop anemia, but did have methemoglobinemia and Heinz bodies as well as complaints of headache and vertigo. Listed in the table "Examples of Industrial Chemicals for Which Methemoglobin Formation is NOT the Principal Cause of Toxicity"; [ACGIH] Evidence of liver injury in high-dose feeding studies of rats; [HSDB]

Reference Link

NIOSH Occupational Health Guidelines for Chemical Hazards: o-Anisidine

Exposure Assessment
BEI

Methemoglobin in blood = 1.5% of hemoglobin during or at end of shift. [ACGIH]

Skin Designation (ACGIH)

Yes

TLV (ACGIH)

0.5 mg/m3

PEL (OSHA)

0.5 mg/m3

IDLH (NIOSH)

50 mg/m3

Excerpts from Documentation for IDLHs

Other animal data: Mice have survived exposures to concentrations of 10 to 30 mg/m3 for 2 hours/day, 6 days/week for 1 month with only a decrease in the excitability of nerves noted [Zaeva and Fedorova 1962]. Human data: None relevant for use in determining the revised IDLH.

Vapor Pressure

0.08 mm Hg

Explanatory Notes

Flash point = 118 deg C;

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

Methemoglobinemia

Methemoglobinemia, Secondary

IARC Carcinogen

Possible Carcinogen

ACGIH Carcinogen

Confirmed Animal

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Related Information in HazMap
Other Information

No other related information on this agent was found.