Agent Name

2,4,5,2',4',5'-Hexabromobiphenyl

CAS Number

59080-40-9

Formula

C12-H4-Br6

Major Category

Plastics & Rubber

Synonyms

1,1'-Biphenyl, 2,2',4,4',5,5'-hexabromo-; 2,2',4,4',5,5'-Hexabromobiphenyl; 2,2',4,4',5,5'-Hexabromo-1,1'-biphenyl; Hexabromobiphenyl; [ChemIDplus]

Category

Other Plasticizers

Description

White solid; [HSDB]

Sources/Uses

Used as a fire retardant for ABS plastics, coatings, lacquers, and polyurethane foams; Hexabromobiphenyl is resistant to degradation in the environment. It was a major constituent of Firemaster BP-6 and Firemaster FF-1 used in plastic components in televisions and computers. Commercial production and use ceased in the US in 1974; [HSDB]

Comments

No increased cancer deaths were found in a group of 3500 workers exposed to polybrominated biphenyls from 1935 to 1976 in a chemical plant. Cattle feed was contaminated with hexabromobiphenyl in 1973; it was used by farmer in Michigan from 1973-1974. Polybrominated biphenyls are possibly carcinogenic to humans (Group 2B). [IARC] Evidence of hepatotoxicity, neuromuscular dysfunction, reproductive toxicity, and liver tumors in high-dose animal studies; [HSDB] PBBs can cause chloracne and liver toxicity to workers exposed to high doses absorbed through the skin or by inhalation. [ATSDR ToxFAQs] See "Polybrominated biphenyls."

Reference Link

ATSDR - ToxFAQs: Polybrominated Biphenyls (PBBs)

Exposure Assessment
Bioaccumulates

Yes

Vapor Pressure

5.2E-8 mm Hg

Half Life

Biological half-life in guinea pigs = 22 days; Estimated body burden t1/2 in man = 6.5 years; [HSDB]

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

Reproductive Toxin

Yes

Dermatotoxin

Chloracne

IARC Carcinogen

Possible Carcinogen

Links to Other NLM Databases
Health Studies

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Chemical Information

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Diseases

Occupational diseases associated with exposure to this agent:

Processes

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