Agent Name

2,6-Diaminotoluene

CAS Number

823-40-5

Formula

C7-H10-N2

Major Category

Nitrogen Compounds

Synonyms

1,3-Benzenediamine, 2-methyl-; 2,6-Diamino-1-methylbenzene; 2,6-Toluylenediamine; 2,6-Tolylenediamine; 2-Methyl-1,3-benzenediamine; 2-Methyl-1,3-phenylenediamine; 2-Methyl-m-phenylenediamine; Toluene, 2,6-diamino-; Toluene-2,6-diamine; o-Toluene diamine; [ChemIDplus]

Category

Amines, Aromatic

Description

Colorless solid; Turns brown when exposed to air; [ICSC] White to brown solid; [MSDSonline]

Sources/Uses

Used as a chemical intermediate for toluene diisocyanate; in the production of polyurethane foam, elastomers, polyether polyols, dyes, and rubber chemicals; as a curing agent for epoxy resins; and as a monomer, chain extender, and crosslinker for polymers; [HSDB] Commercially available as 80:20 mixture of the meta (2,4 and 2,6) isomers; The commercial mixture may be represented by CAS #'s 25376-45-8 and 26966-75-6 (although these CAS #s may also be used for other isomeric mixtures); [OECD SIDS] Meta-DAT (80:20 or 65:35 mixture of 2,4 and 2,6 isomers): Used to make urethane products, dyes, corrosion inhibitors, and rubber antioxidants; [INCHEM]

Comments

Exhibits the same genotoxic behavior in the Ames Salmonella assay as the 2,4 isomer, and both compounds metabolites are mutagenic with metabolic activation; Unlike the 2,4 isomer, which is a strong hepatocarcinogen, the 2,6 isomer produced no increase in tumor frequency in rodent bioassays; Emergency treatment: Methemoglobinemia; [HSDB] A skin, eye, and respiratory tract irritant; Can induce methemoglobinemia; May cause skin sensitization; Can be absorbed through skin; [ICSC] May cause skin sensitization; [eChemPortal: ESIS] Mutagenic; [RTECS] See "2,4-Diaminotoluene."

Adverse Effects
Skin Sensitizer

Yes

Hepatotoxin

Hepatotoxin, Secondary

Reproductive Toxin

Yes

Methemoglobinemia

Methemoglobinemia, Secondary

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