Agent Name

2,6-Diethylaniline

CAS Number

579-66-8

Formula

C10-H15-N

Major Category

Nitrogen Compounds

Synonyms

2,6-Diethyl aniline; 2,6-Diethylbenzenamine; Aniline, 2,6-diethyl-; Benzenamine, 2,6-diethyl-; [ChemIDplus]

Category

Amines, Aromatic

Description

Yellow liquid; [HSDB] Colorless liquid; [MSDSonline]

Sources/Uses

Used to make pesticides, triazine herbicides, dyestuffs, antioxidants, pharmaceuticals, synthetic resins, fragrances, and other products; Also found in soil as microbial metabolite of some acetanilide herbicides, including alachlor; [HSDB]

Comments

Emergency treatment: Methemoglobinemia; [HSDB] Cyanosis observed in oral lethal-dose study of rats; No significant pathological changes observed; Effects in lethal-concentration inhalation study with rats include bronchial pneumonia, hemorrhage and edema of the lungs, congestion and focal necrosis of the liver, and cloudy swelling in the kidneys; No adverse changes in blood or clinical chemistries, or gross or histopathological examinations observed in 90-day inhalation study of rats; Histopathological changes of liver in other high-dose studies with rats and dogs; Teratogenic effects (decrease in fetal weight and retarded ossification) observed in gavage study with rats at doses maternally toxic; Irritating to rabbit eyes, but not to skin; Not sensitizing or irritating to guinea pig skin; [EPA HPVIS]

Exposure Assessment
Vapor Pressure

0.00383 mm Hg

Lethal Concentration

LC50 (rat) = 4,700 mg/m3/6h

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

Methemoglobinemia

Methemoglobinemia, Secondary

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Other Information

No other related information on this agent was found.